{"entity":{"id":"caron-jacobson","kind":"person","name":"Caron A. Jacobson","aka":[],"tldr":"Boston lymphoma doctor who led ZUMA-5, the trial that brought the CAR-T therapy axicabtagene ciloleucel to relapsed follicular lymphoma.","summary":"Caron Jacobson leads the immune effector cell therapy programme at Dana-Farber Cancer Institute. She was first author of the 2022 Lancet Oncology report of ZUMA-5, the phase 2 trial in which axicabtagene ciloleucel produced high and durable response rates in relapsed or refractory indolent non-Hodgkin lymphoma, the basis for its approval in follicular lymphoma. She also investigates CAR-T therapy in large B-cell lymphoma.","asOf":"2026-09-18","links":[],"tags":["lymphoma","car-t","cell-therapy","trialist"],"related":[],"cancers":["follicular-lymphoma","marginal-zone-lymphoma","non-hodgkin-lymphoma"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":["dana-farber"],"pathways":[],"terms":[],"trials":["zuma-5"],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"role":"Lymphoma specialist and medical director of immune effector cell therapy, Dana-Farber Cancer Institute","institutionId":"dana-farber","specialisms":["CAR-T cell therapy","Follicular lymphoma","Large B-cell lymphoma"],"profiles":[{"label":"PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/?term=Jacobson%5BAuthor%5D"}],"papers":[]},"route":"/people/caron-jacobson/","neighbours":{"cancer":[{"id":"follicular-lymphoma","kind":"cancer","name":"Follicular lymphoma","route":"/cancers/follicular-lymphoma/"},{"id":"marginal-zone-lymphoma","kind":"cancer","name":"Marginal zone lymphoma","route":"/cancers/marginal-zone-lymphoma/"},{"id":"non-hodgkin-lymphoma","kind":"cancer","name":"Non-Hodgkin lymphoma (all types)","route":"/cancers/non-hodgkin-lymphoma/"}],"institution":[{"id":"dana-farber","kind":"institution","name":"Dana-Farber Brigham Cancer Center","route":"/institutions/dana-farber/"}],"trial":[{"id":"zuma-5","kind":"trial","name":"ZUMA-5","route":"/trials/zuma-5/"}]}}