{"entity":{"id":"cars1","kind":"target","name":"CARS1","aka":["cysteinyl-tRNA synthetase 1","Cysteine--tRNA ligase, cytoplasmic"],"tldr":"CARS1 (Cysteine--tRNA ligase, cytoplasmic) is an enzyme. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role. Tied to Skin cancer, Lung cancer and Melanoma.","summary":"Catalyses the ATP-dependent ligation of cysteine to tRNA(Cys).\n\nOpen Targets scores its association with cancer at 0.71 (direct and indirect evidence; datatypes literature 0.54, affected pathway 0.76, genetic association 0.00, somatic mutation 0.97).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:1493","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:1493"},{"label":"UniProt P49589","url":"https://www.uniprot.org/uniprotkb/P49589/entry"},{"label":"NCBI Gene 833","url":"https://www.ncbi.nlm.nih.gov/gene/833"},{"label":"Ensembl ENSG00000110619","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000110619"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":["skin-cancer","lung-cancer","melanoma"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: UniProt disease notes describe a translocation or gene fusion involving the gene. Evidence tier \"association-only\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"CARS1","role":["fusion-partner"],"evidenceTier":"association-only","sources":[{"label":"HGNC HGNC:1493","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:1493","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt P49589","url":"https://www.uniprot.org/uniprotkb/P49589/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000110619","url":"https://platform.opentargets.org/target/ENSG00000110619/associations","note":"association with cancer (MONDO_0004992) 0.71; per-cancer scores at or above 0.5: melanoma 0.50, skin cancer 0.54, lung cancer 0.50 (GraphQL API, CC0)"}],"hgnc":"HGNC:1493","ensembl":"ENSG00000110619","uniprot":"P49589","entrez":"833","biology":"Catalyses the ATP-dependent ligation of cysteine to tRNA(Cys). Location: Cytoplasm (UniProt). Locus 11p15.4 (HGNC).","whereFound":["Skin cancer: Open Targets association 0.54 with skin cancer (MONDO_0002898)","Lung cancer: Open Targets association 0.50 with lung cancer (MONDO_0008903)","Melanoma: Open Targets association 0.50 with melanoma (MONDO_0005105)"],"targetClass":"enzyme","prevalence":[]},"route":"/targets/cars1/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"lung-cancer","kind":"cancer","name":"Lung cancer (all types)","route":"/cancers/lung-cancer/"},{"id":"melanoma","kind":"cancer","name":"Melanoma","route":"/cancers/melanoma/"},{"id":"skin-cancer","kind":"cancer","name":"Skin cancer (all types)","route":"/cancers/skin-cancer/"}]}}