{"entity":{"id":"cartesian-therapeutics","kind":"company","name":"Cartesian Therapeutics","aka":["Cartesian Therapeutics, Inc.","Cartesian"],"tldr":"Cartesian makes CAR-T cells from messenger RNA rather than permanent gene insertion, so the cells work for days and then fade; it began in myeloma and now leads phase 3 trials in autoimmune disease.","summary":"Cartesian Therapeutics, based in Frederick, Maryland, engineers T cells with mRNA-encoded chimeric antigen receptors, giving a transient product that can be dosed repeatedly without lymphodepletion. Its BCMA-directed Descartes-08 was first tested in multiple myeloma before the company focused on myasthenia gravis and other autoimmune diseases, where it leads phase 3 trials. Its myeloma trials remain on ClinicalTrials.gov under Cartesian as lead sponsor.","asOf":"2026-09-11","links":[{"label":"Official website","url":"https://www.cartesiantherapeutics.com"},{"label":"ClinicalTrials.gov: trials led by Cartesian Therapeutics, Inc.","url":"https://clinicaltrials.gov/search?lead=Cartesian%20Therapeutics%2C%20Inc."},{"label":"Wikidata","url":"https://www.wikidata.org/wiki/Q140045331"}],"tags":["ctgov-sponsor"],"related":[],"cancers":["multiple-myeloma"],"sections":[],"technologies":["car-t"],"targets":["bcma"],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":["pivotal-trial","clinical-trial"],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"notes":[],"provenance":{"editedBy":"OnCo ingestion (ClinicalTrials.gov v2 + sponsor websites)","editedOn":"2026-09-11"},"hq":"Frederick, MD","country":"US","companyType":"cell-therapy","website":"https://www.cartesiantherapeutics.com","stage":"public","investors":[],"funding":[]},"route":"/companies/cartesian-therapeutics/","neighbours":{"cancer":[{"id":"multiple-myeloma","kind":"cancer","name":"Multiple myeloma","route":"/cancers/multiple-myeloma/"}],"technology":[{"id":"car-t","kind":"technology","name":"CAR-T cell therapy","route":"/technologies/car-t/"}],"target":[{"id":"bcma","kind":"target","name":"BCMA","route":"/targets/bcma/"}],"term":[{"id":"clinical-trial","kind":"term","name":"Clinical trial","route":"/terms/clinical-trial/"},{"id":"pivotal-trial","kind":"term","name":"Pivotal (registrational) trial","route":"/terms/pivotal-trial/"}]}}