{"entity":{"id":"casp10","kind":"target","name":"CASP10","aka":["caspase 10","Caspase-10","MCH4","FLICE-2"],"tldr":"CASP10 (Caspase-10) is an enzyme. In the public catalogues the evidence so far is association rather than a proven role. Tied to Gastric & gastro-oesophageal junction cancer and Non-Hodgkin lymphoma.","summary":"Involved in the activation cascade of caspases responsible for apoptosis execution. Recruited to both Fas- and TNFR-1 receptors in a FADD dependent manner. May participate in the granzyme B apoptotic pathways.\n\nOpen Targets scores its association with cancer at 0.57 (direct and indirect evidence; datatypes literature 0.74, genetic association 0.52, somatic mutation 0.68, genetic literature 0.61).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:1500","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:1500"},{"label":"UniProt Q92851","url":"https://www.uniprot.org/uniprotkb/Q92851/entry"},{"label":"NCBI Gene 843","url":"https://www.ncbi.nlm.nih.gov/gene/843"},{"label":"Ensembl ENSG00000003400","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000003400"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":["gastric","non-hodgkin-lymphoma"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier \"association-only\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"CASP10","role":[],"evidenceTier":"association-only","sources":[{"label":"HGNC HGNC:1500","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:1500","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q92851","url":"https://www.uniprot.org/uniprotkb/Q92851/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000003400","url":"https://platform.opentargets.org/target/ENSG00000003400/associations","note":"association with cancer (MONDO_0004992) 0.57; per-cancer scores at or above 0.5: gastric cancer 0.56, non-Hodgkin lymphoma 0.55 (GraphQL API, CC0)"}],"hgnc":"HGNC:1500","ensembl":"ENSG00000003400","uniprot":"Q92851","entrez":"843","biology":"Involved in the activation cascade of caspases responsible for apoptosis execution. Recruited to both Fas- and TNFR-1 receptors in a FADD dependent manner. May participate in the granzyme B apoptotic pathways. Cleaves and activates effector caspases CASP3, CASP4, CASP6, CASP7, CASP8 and CASP9. Hydrolyses the small- molecule substrates, Tyr-Val-Ala-Asp-|-AMC and Asp-Glu-Val-Asp-|-AMC. Isoform 7 can enhance NF-kappaB activity but promotes only slight apoptosis. Locus 2q33.1 (HGNC).","whereFound":["Gastric & gastro-oesophageal junction cancer: Open Targets association 0.56 with gastric cancer (MONDO_0001056)","Non-Hodgkin lymphoma: Open Targets association 0.55 with non-Hodgkin lymphoma (MONDO_0018908)"],"targetClass":"enzyme","prevalence":[]},"route":"/targets/casp10/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"gastric","kind":"cancer","name":"Gastric & gastro-oesophageal junction cancer","route":"/cancers/gastric/"},{"id":"non-hodgkin-lymphoma","kind":"cancer","name":"Non-Hodgkin lymphoma (all types)","route":"/cancers/non-hodgkin-lymphoma/"}]}}