{"entity":{"id":"cb-101","kind":"drug","name":"CB-101","aka":[],"tldr":"CB-101 is a three-armed antibody from XTOP Biotherapeutics that steers T cells to tumour cells carrying both ROR1 and EpCAM, in laboratory development for colon, pancreatic and lung cancers.","summary":"CB-101 is the lead programme of XTOP Biotherapeutics, built on its CrossBody platform and described on its pipeline page as a tumour-specific and tumour-associated antigen AND-gate trispecific T-cell engager for colon, pancreatic and lung cancers. The NCI SBIR award that funds its study (1R43CA310454-01A1) names ROR1, EpCAM and CD3 as its targets. No clinical trial is registered.","status":"preclinical","asOf":"2026-11-04","links":[{"label":"XTOP Biotherapeutics pipeline","url":"https://www.xtopbiotherapeutics.com/pipeline/pipeline"},{"label":"NIH RePORTER: 1R43CA310454-01A1","url":"https://reporter.nih.gov/project-details/11407471"}],"tags":["pipeline"],"related":[],"cancers":[],"sections":[],"technologies":["trispecific-antibodies"],"targets":["ror1","epcam","cd3"],"drugs":[],"companies":["xtop-biotherapeutics"],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"provenance":{"editedBy":"OnCo startup monitors","editedOn":"2026-11-04"},"code":"CB-101","modality":"Trispecific antibody (T-cell engager)","mechanism":"A trispecific T-cell engager that, according to its NCI award, binds ROR1 and EpCAM on tumour cells and CD3 on T cells; the company describes it as an AND-gate design that needs both tumour antigens present.","approvals":[],"mechanismSteps":[],"toxicity":[],"access":[],"regulatoryEvents":[]},"route":"/drugs/cb-101/","neighbours":{"technology":[{"id":"trispecific-antibodies","kind":"technology","name":"Trispecific antibodies","route":"/technologies/trispecific-antibodies/"}],"target":[{"id":"cd3","kind":"target","name":"CD3","route":"/targets/cd3/"},{"id":"epcam","kind":"target","name":"EpCAM","route":"/targets/epcam/"},{"id":"ror1","kind":"target","name":"ROR1","route":"/targets/ror1/"}],"company":[{"id":"xtop-biotherapeutics","kind":"company","name":"XTOP Biotherapeutics","route":"/companies/xtop-biotherapeutics/"}]}}