{"entity":{"id":"cbi-1214","kind":"drug","name":"CBI-1214","aka":[],"tldr":"CBI-1214 is an experimental bispecific T cell engager from Cartography Biosciences, in phase 1 trials for microsatellite-stable or MSI-low metastatic colorectal cancer.","summary":"CBI-1214 is a bispecific T cell engager from Cartography Biosciences. A bispecific T cell engager that binds LY6G6D on colorectal cancer cells and CD3 on T cells, linking the patient's T cells to the cancer cells to kill them. Its furthest stage is phase 1, for microsatellite-stable or MSI-low metastatic colorectal cancer. ClinicalTrials.gov registers it in one study linked below. Phase 1 NCT07321106 recruiting, started 15 January 2026. Whether it works in people has not been established unless a trial below reports it.","status":"phase-1","asOf":"2026-11-03","links":[{"label":"Cartography Biosciences: clinicaltrials.gov","url":"https://clinicaltrials.gov/study/NCT07321106"},{"label":"ClinicalTrials.gov: trials of CBI-1214","url":"https://clinicaltrials.gov/search?intr=CBI-1214"}],"tags":["pipeline","ctgov-ingest"],"related":[],"cancers":["colorectal"],"sections":[],"technologies":[],"targets":["cd3"],"drugs":[],"companies":["cartography-biosciences"],"institutions":[],"pathways":[],"terms":[],"trials":["nct07321106"],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"provenance":{"editedBy":"OnCo gap audit, class 5 (company pipeline pages and ClinicalTrials.gov v2)","editedOn":"2026-11-03"},"code":"CBI-1214","modality":"Bispecific T cell engager","mechanism":"A bispecific T cell engager that binds LY6G6D on colorectal cancer cells and CD3 on T cells, linking the patient's T cells to the cancer cells to kill them.","approvals":[],"mechanismSteps":[],"toxicity":[],"access":[],"regulatoryEvents":[]},"route":"/drugs/cbi-1214/","neighbours":{"cancer":[{"id":"colorectal","kind":"cancer","name":"Colorectal cancer","route":"/cancers/colorectal/"}],"target":[{"id":"cd3","kind":"target","name":"CD3","route":"/targets/cd3/"}],"company":[{"id":"cartography-biosciences","kind":"company","name":"Cartography Biosciences","route":"/companies/cartography-biosciences/"}],"trial":[{"id":"nct07321106","kind":"trial","name":"A Study to Investigate the Safety, Tolerability, Pharmacokinetics, and Anti-tumor Activity of CBI-1214 T Cell Engager in Participants With Advanced or Metastatic MSS/MSI-L Colorectal Cancer","route":"/trials/nct07321106/"}]}}