{"entity":{"id":"ccar1","kind":"target","name":"CCAR1","aka":["cell division cycle and apoptosis regulator 1","Cell division cycle and apoptosis regulator protein 1","CARP1","CARP-1","uc.285+","FLJ10590"],"tldr":"CCAR1 (Cell division cycle and apoptosis regulator protein 1) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Medulloblastoma.","summary":"Associates with components of the Mediator and p160 coactivator complexes that play a role as intermediaries transducing regulatory signals from upstream transcriptional activator proteins to basal transcription machinery at the core promoter. Recruited to endogenous nuclear receptor target genes in response to the appropriate hormone. Also functions as a p53 coactivator.\n\nIntOGen calls it a driver in 1 cohort (0 activating, 1 loss-of-function), covering Medulloblastoma.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:24236","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:24236"},{"label":"UniProt Q8IX12","url":"https://www.uniprot.org/uniprotkb/Q8IX12/entry"},{"label":"NCBI Gene 55749","url":"https://www.ncbi.nlm.nih.gov/gene/55749"},{"label":"Ensembl ENSG00000060339","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000060339"}],"tags":["cancer-genes-wave"],"related":["intogen"],"cancers":["medulloblastoma"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it a loss-of-function (LoF) driver in 1 cohort. Evidence tier \"cohort-driver\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"CCAR1","role":["tumour-suppressor"],"evidenceTier":"cohort-driver","sources":[{"label":"HGNC HGNC:24236","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:24236","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q8IX12","url":"https://www.uniprot.org/uniprotkb/Q8IX12/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"IntOGen CCAR1","url":"https://www.intogen.org/search?gene=CCAR1","note":"driver in 1 cohort (Act 0, LoF 1); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0"}],"hgnc":"HGNC:24236","ensembl":"ENSG00000060339","uniprot":"Q8IX12","entrez":"55749","biology":"Associates with components of the Mediator and p160 coactivator complexes that play a role as intermediaries transducing regulatory signals from upstream transcriptional activator proteins to basal transcription machinery at the core promoter. Recruited to endogenous nuclear receptor target genes in response to the appropriate hormone. Also functions as a p53 coactivator. May thus play an important role in transcriptional regulation. May be involved in apoptosis signalling in the presence of the reinoid CD437. Apoptosis induction involves sequestration of 14-3-3 protein(s) and mediated altered expression of multiple cell cycle regulatory genes including MYC, CCNB1 and CDKN1A. Location: Cytoplasm, perinuclear region (UniProt). Locus 10q21.3 (HGNC).","whereFound":["Medulloblastoma: IntOGen driver in 1 cohort (MBL)"],"targetClass":"tumor-suppressor","prevalence":[]},"route":"/targets/ccar1/","neighbours":{"collection":[{"id":"intogen","kind":"collection","name":"IntOGen","route":"/collections/intogen/"}],"cancer":[{"id":"medulloblastoma","kind":"cancer","name":"Medulloblastoma","route":"/cancers/medulloblastoma/"}]}}