{"entity":{"id":"ccdc170","kind":"target","name":"CCDC170","aka":["coiled-coil domain containing 170","Coiled-coil domain-containing protein 170","FLJ23305","bA282P11.1","C6orf97"],"tldr":"CCDC170 (Coiled-coil domain-containing protein 170) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Breast cancer.","summary":"Plays a role in Golgi-associated microtubules organisation and stabilisation.\n\nOpen Targets scores its association with cancer at 0.55 (direct and indirect evidence; datatypes literature 0.94, genetic association 0.68).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:21177","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:21177"},{"label":"UniProt Q8IYT3","url":"https://www.uniprot.org/uniprotkb/Q8IYT3/entry"},{"label":"NCBI Gene 80129","url":"https://www.ncbi.nlm.nih.gov/gene/80129"},{"label":"Ensembl ENSG00000120262","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000120262"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":["breast-cancer"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier \"association-only\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"CCDC170","role":[],"evidenceTier":"association-only","sources":[{"label":"HGNC HGNC:21177","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:21177","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q8IYT3","url":"https://www.uniprot.org/uniprotkb/Q8IYT3/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000120262","url":"https://platform.opentargets.org/target/ENSG00000120262/associations","note":"association with cancer (MONDO_0004992) 0.55; per-cancer scores at or above 0.5: breast cancer 0.54 (GraphQL API, CC0)"}],"hgnc":"HGNC:21177","ensembl":"ENSG00000120262","uniprot":"Q8IYT3","entrez":"80129","biology":"Plays a role in Golgi-associated microtubules organisation and stabilisation. Location: Golgi apparatus (UniProt). Locus 6q25.1 (HGNC).","whereFound":["Breast cancer: Open Targets association 0.54 with breast cancer (MONDO_0007254)"],"targetClass":"other","prevalence":[]},"route":"/targets/ccdc170/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"breast-cancer","kind":"cancer","name":"Breast cancer (all types)","route":"/cancers/breast-cancer/"}]}}