{"entity":{"id":"ccn2","kind":"target","name":"CCN2","aka":["cellular communication network factor 2","CCN family member 2","IGFBP8"],"tldr":"CCN2 (CCN family member 2) is a gene. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response.","summary":"Major connective tissue mitoattractant secreted by vascular endothelial cells. Promotes proliferation and differentiation of chondrocytes. Is involved in the stimulation of osteoblast differentiation and has a critical role in osteogenesis.\n\nCIViC holds 1 clinical evidence item and 0 assertions across 1 variant.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:2500","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:2500"},{"label":"UniProt P29279","url":"https://www.uniprot.org/uniprotkb/P29279/entry"},{"label":"NCBI Gene 1490","url":"https://www.ncbi.nlm.nih.gov/gene/1490"},{"label":"Ensembl ENSG00000118523","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000118523"}],"tags":["cancer-genes-wave"],"related":["civic"],"cancers":[],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC holds 1 clinical evidence items on its variants. Evidence tier \"clinical-evidence\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate.","Diseases the sources name that have no OnCo cancer page yet, so they are not linked: Glioma."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"CCN2","role":["biomarker"],"evidenceTier":"clinical-evidence","sources":[{"label":"HGNC HGNC:2500","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:2500","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt P29279","url":"https://www.uniprot.org/uniprotkb/P29279/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"CIViC gene CCN2","url":"https://civicdb.org/features/1283","note":"1 evidence items, 0 assertions, 1 variants; diseases: Glioma (GraphQL API, CC0)"}],"hgnc":"HGNC:2500","ensembl":"ENSG00000118523","uniprot":"P29279","entrez":"1490","biology":"Major connective tissue mitoattractant secreted by vascular endothelial cells. Promotes proliferation and differentiation of chondrocytes. Is involved in the stimulation of osteoblast differentiation and has a critical role in osteogenesis. Mediates heparin- and divalent cation-dependent cell adhesion in many cell types including fibroblasts, myofibroblasts, endothelial and epithelial cells. Enhances fibroblast growth factor-induced DNA synthesis. Location: Secreted, extracellular space, extracellular matrix; Secreted (UniProt). Locus 6q23.2 (HGNC).","whereFound":[],"targetClass":"other","prevalence":[]},"route":"/targets/ccn2/","neighbours":{"collection":[{"id":"civic","kind":"collection","name":"CIViC","route":"/collections/civic/"}]}}