{"entity":{"id":"ccnb1ip1","kind":"target","name":"CCNB1IP1","aka":["cyclin B1 interacting protein 1","E3 ubiquitin-protein ligase CCNB1IP1","HEI10","C14orf18"],"tldr":"CCNB1IP1 (E3 ubiquitin-protein ligase CCNB1IP1) is an enzyme. In the public catalogues the evidence so far is association rather than a proven role. Tied to Skin cancer.","summary":"Ubiquitin E3 ligase that acts as a limiting factor for crossing-over during meiosis: required during zygonema to limit the colocalisation of RNF212 with MutS-gamma-associated recombination sites and thereby establish early differentiation of crossover and non-crossover sites. Later, it is directed by MutL-gamma to stably accumulate at designated crossover sites. Probably promotes the dissociation of RNF212 and MutS-gamma to allow the progression of recombination and the implementation of the final steps of crossing over.\n\nOpen Targets scores its association with cancer at 0.58 (direct and indirect evidence; datatypes literature 0.19, genetic association 0.00, somatic mutation 0.95).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:19437","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:19437"},{"label":"UniProt Q9NPC3","url":"https://www.uniprot.org/uniprotkb/Q9NPC3/entry"},{"label":"NCBI Gene 57820","url":"https://www.ncbi.nlm.nih.gov/gene/57820"},{"label":"Ensembl ENSG00000100814","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000100814"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":["skin-cancer"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier \"association-only\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"CCNB1IP1","role":[],"evidenceTier":"association-only","sources":[{"label":"HGNC HGNC:19437","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:19437","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q9NPC3","url":"https://www.uniprot.org/uniprotkb/Q9NPC3/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000100814","url":"https://platform.opentargets.org/target/ENSG00000100814/associations","note":"association with cancer (MONDO_0004992) 0.58; per-cancer scores at or above 0.5: skin cancer 0.51 (GraphQL API, CC0)"}],"hgnc":"HGNC:19437","ensembl":"ENSG00000100814","uniprot":"Q9NPC3","entrez":"57820","biology":"Ubiquitin E3 ligase that acts as a limiting factor for crossing-over during meiosis: required during zygonema to limit the colocalisation of RNF212 with MutS-gamma-associated recombination sites and thereby establish early differentiation of crossover and non-crossover sites. Later, it is directed by MutL-gamma to stably accumulate at designated crossover sites. Probably promotes the dissociation of RNF212 and MutS-gamma to allow the progression of recombination and the implementation of the final steps of crossing over. Modulates cyclin-B levels and participates in the regulation of cell cycle progression through the G2 phase. Overexpression causes delayed entry into mitosis. Location: Nucleus; Chromosome (UniProt). Locus 14q11.2 (HGNC).","whereFound":["Skin cancer: Open Targets association 0.51 with skin cancer (MONDO_0002898)"],"targetClass":"enzyme","prevalence":[]},"route":"/targets/ccnb1ip1/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"skin-cancer","kind":"cancer","name":"Skin cancer (all types)","route":"/cancers/skin-cancer/"}]}}