{"entity":{"id":"ccne1","kind":"target","name":"CCNE1","aka":["cyclin E1","G1/S-specific cyclin-E1"],"tldr":"CCNE1 (G1/S-specific cyclin-E1) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Gastric & gastro-oesophageal junction cancer, Breast cancer, Ovarian cancer and 5 more.","summary":"Essential for the control of the cell cycle at the G1/S (start) transition.\n\nCIViC holds 16 clinical evidence items and 0 assertions across 3 variants, naming Palbociclib, Dinaciclib, CDK Inhibitor SNS-032 and Camonsertib and others. Open Targets scores its association with cancer at 0.74 (direct and indirect evidence; datatypes affected pathway 0.57, literature 0.99, genetic association 0.57, somatic mutation 0.96, animal model 0.64). In OnCo, 1 product record names it (AVZO-021).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:1589","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:1589"},{"label":"UniProt P24864","url":"https://www.uniprot.org/uniprotkb/P24864/entry"},{"label":"NCBI Gene 898","url":"https://www.ncbi.nlm.nih.gov/gene/898"},{"label":"Ensembl ENSG00000105173","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000105173"}],"tags":["cancer-genes-wave"],"related":["civic","open-targets"],"cancers":["gastric","breast-cancer","ovarian","endometrial","colorectal","urothelial","skin-cancer","breast-hr-positive"],"sections":[],"technologies":[],"targets":[],"drugs":["avzo-021"],"companies":[],"institutions":[],"pathways":["synthetic-lethality-map"],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC lists 10 therapies; CIViC holds 16 clinical evidence items on its variants. Evidence tier \"clinical-evidence\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate.","Diseases the sources name that have no OnCo cancer page yet, so they are not linked: Gastric Adenosquamous Carcinoma; Ovarian Serous Cystadenocarcinoma; Endometrial Serous Adenocarcinoma."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"CCNE1","role":["drug-target","biomarker"],"evidenceTier":"clinical-evidence","sources":[{"label":"HGNC HGNC:1589","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:1589","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt P24864","url":"https://www.uniprot.org/uniprotkb/P24864/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"CIViC gene CCNE1","url":"https://civicdb.org/features/11","note":"16 evidence items, 0 assertions, 3 variants; diseases: Ovarian Cancer, Breast Cancer, Gastric Adenosquamous Carcinoma, Ovarian Carcinoma, Stomach Cancer and 4 more (GraphQL API, CC0)"},{"label":"Open Targets ENSG00000105173","url":"https://platform.opentargets.org/target/ENSG00000105173/associations","note":"association with cancer (MONDO_0004992) 0.74; per-cancer scores at or above 0.5: colorectal cancer 0.58, gastric cancer 0.51, urinary bladder cancer 0.52, skin cancer 0.50, breast cancer 0.50 (GraphQL API, CC0)"}],"hgnc":"HGNC:1589","ensembl":"ENSG00000105173","uniprot":"P24864","entrez":"898","biology":"Essential for the control of the cell cycle at the G1/S (start) transition. Location: Nucleus (UniProt). Locus 19q12 (HGNC).","whereFound":["Gastric & gastro-oesophageal junction cancer: Open Targets association 0.51 with gastric cancer (MONDO_0001056); CIViC evidence names this disease","Breast cancer: Open Targets association 0.50 with breast cancer (MONDO_0007254); CIViC evidence names this disease","Ovarian cancer: CIViC evidence names this disease","Endometrial cancer: CIViC evidence names this disease","Colorectal cancer: Open Targets association 0.58 with colorectal cancer (MONDO_0005575)","Bladder & urothelial cancer: Open Targets association 0.52 with urinary bladder cancer (MONDO_0001187)"],"targetClass":"other","prevalence":[]},"route":"/targets/ccne1/","neighbours":{"collection":[{"id":"civic","kind":"collection","name":"CIViC","route":"/collections/civic/"},{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"urothelial","kind":"cancer","name":"Bladder & urothelial cancer","route":"/cancers/urothelial/"},{"id":"breast-cancer","kind":"cancer","name":"Breast cancer (all types)","route":"/cancers/breast-cancer/"},{"id":"colorectal","kind":"cancer","name":"Colorectal cancer","route":"/cancers/colorectal/"},{"id":"endometrial","kind":"cancer","name":"Endometrial cancer","route":"/cancers/endometrial/"},{"id":"gastric","kind":"cancer","name":"Gastric & gastro-oesophageal junction cancer","route":"/cancers/gastric/"},{"id":"breast-hr-positive","kind":"cancer","name":"HR-positive / HER2-negative breast cancer","route":"/cancers/breast-hr-positive/"},{"id":"ovarian","kind":"cancer","name":"Ovarian cancer","route":"/cancers/ovarian/"},{"id":"skin-cancer","kind":"cancer","name":"Skin cancer (all types)","route":"/cancers/skin-cancer/"}],"drug":[{"id":"avzo-021","kind":"drug","name":"AVZO-021","route":"/drugs/avzo-021/"}],"pathway":[{"id":"synthetic-lethality-map","kind":"pathway","name":"Synthetic lethality: paired dependencies","route":"/pathways/synthetic-lethality-map/"}]}}