{"entity":{"id":"ccne2","kind":"target","name":"CCNE2","aka":["cyclin E2","G1/S-specific cyclin-E2","CYCE2"],"tldr":"CCNE2 (G1/S-specific cyclin-E2) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Breast cancer.","summary":"Essential for the control of the cell cycle at the late G1 and early S phase.\n\nCIViC holds 2 clinical evidence items and 0 assertions across 1 variant, naming Palbociclib and CDK Inhibitor SNS-032.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:1590","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:1590"},{"label":"UniProt O96020","url":"https://www.uniprot.org/uniprotkb/O96020/entry"},{"label":"NCBI Gene 9134","url":"https://www.ncbi.nlm.nih.gov/gene/9134"},{"label":"Ensembl ENSG00000175305","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000175305"}],"tags":["cancer-genes-wave"],"related":["civic"],"cancers":["breast-cancer"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC lists 2 therapies; CIViC holds 2 clinical evidence items on its variants. Evidence tier \"clinical-evidence\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"CCNE2","role":["drug-target","biomarker"],"evidenceTier":"clinical-evidence","sources":[{"label":"HGNC HGNC:1590","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:1590","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt O96020","url":"https://www.uniprot.org/uniprotkb/O96020/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"CIViC gene CCNE2","url":"https://civicdb.org/features/7222","note":"2 evidence items, 0 assertions, 1 variants; diseases: Breast Cancer (GraphQL API, CC0)"}],"hgnc":"HGNC:1590","ensembl":"ENSG00000175305","uniprot":"O96020","entrez":"9134","biology":"Essential for the control of the cell cycle at the late G1 and early S phase. Location: Nucleus (UniProt). Locus 8q22.1 (HGNC).","whereFound":["Breast cancer: CIViC evidence names this disease"],"targetClass":"other","prevalence":[]},"route":"/targets/ccne2/","neighbours":{"collection":[{"id":"civic","kind":"collection","name":"CIViC","route":"/collections/civic/"}],"cancer":[{"id":"breast-cancer","kind":"cancer","name":"Breast cancer (all types)","route":"/cancers/breast-cancer/"}]}}