{"entity":{"id":"ccnt1","kind":"target","name":"CCNT1","aka":["cyclin T1","Cyclin-T1","CYCT1","HIVE1"],"tldr":"CCNT1 (Cyclin-T1) is a protein that switches other genes on and off. In the public catalogues it is called a cancer driver by mutation analysis of patient cohorts. Tied to Acute myeloid leukaemia.","summary":"Regulatory subunit of the cyclin-dependent kinase pair (CDK9/cyclin-T1) complex, also called positive transcription elongation factor B (P-TEFb), which facilitates the transition from abortive to productive elongation by phosphorylating the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNA Pol II). Required to activate the protein kinase activity of CDK9: acts by mediating formation of liquid-liquid phase separation (LLPS) that enhances binding of P-TEFb to the CTD of RNA Pol II. Serves as an essential cofactor for Tat, by promoting RNA Pol II activation, allowing transcription of viral genes.\n\nIntOGen calls it a driver in 1 cohort (0 activating, 0 loss-of-function), covering Acute Myeloid Leukaemia.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:1599","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:1599"},{"label":"UniProt O60563","url":"https://www.uniprot.org/uniprotkb/O60563/entry"},{"label":"NCBI Gene 904","url":"https://www.ncbi.nlm.nih.gov/gene/904"},{"label":"Ensembl ENSG00000129315","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000129315"}],"tags":["cancer-genes-wave"],"related":["intogen"],"cancers":["aml"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier \"cohort-driver\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"CCNT1","role":[],"evidenceTier":"cohort-driver","sources":[{"label":"HGNC HGNC:1599","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:1599","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt O60563","url":"https://www.uniprot.org/uniprotkb/O60563/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"IntOGen CCNT1","url":"https://www.intogen.org/search?gene=CCNT1","note":"driver in 1 cohort (Act 0, LoF 0); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0"}],"hgnc":"HGNC:1599","ensembl":"ENSG00000129315","uniprot":"O60563","entrez":"904","biology":"Regulatory subunit of the cyclin-dependent kinase pair (CDK9/cyclin-T1) complex, also called positive transcription elongation factor B (P-TEFb), which facilitates the transition from abortive to productive elongation by phosphorylating the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNA Pol II). Required to activate the protein kinase activity of CDK9: acts by mediating formation of liquid-liquid phase separation (LLPS) that enhances binding of P-TEFb to the CTD of RNA Pol II. Serves as an essential cofactor for Tat, by promoting RNA Pol II activation, allowing transcription of viral genes. Location: Nucleus (UniProt). Locus 12q13.11-q13.12 (HGNC).","whereFound":["Acute myeloid leukaemia: IntOGen driver in 1 cohort (AML)"],"targetClass":"transcription","prevalence":[]},"route":"/targets/ccnt1/","neighbours":{"collection":[{"id":"intogen","kind":"collection","name":"IntOGen","route":"/collections/intogen/"}],"cancer":[{"id":"aml","kind":"cancer","name":"Acute myeloid leukaemia","route":"/cancers/aml/"}]}}