{"entity":{"id":"ccr6","kind":"target","name":"CCR6","aka":[],"tldr":"CCR6 marks the T cells that patrol mucosal surfaces such as the gut and airway, and it is the usual way of picking out the Th17 type of helper cell.","summary":"CCR6 binds CCL20 and directs cells to mucosal tissue, and it is the surface marker conventionally used to identify Th17-polarised helper T cells. In an immune panel it is read together with CXCR3 and CCR4 to assign helper T cells to their functional types, a division that matters when describing what sort of response a tumour or a treatment has provoked.","asOf":"2026-10-16","wikipedia":"https://en.wikipedia.org/wiki/CCR6","links":[{"label":"HGNC:1607","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:1607"}],"tags":["immune-marker"],"related":["ccr4","cxcr5"],"cancers":[],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":["t-cell"],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"symbol":"CCR6","role":[],"sources":[],"specificitySources":[],"biology":"Receptor for CCL20; marks Th17-polarised T cells and directs cells to mucosal tissue.","whereFound":["Th17 cells","Memory T cells","B cells","Dendritic cells"],"targetClass":"surface-antigen","prevalence":[]},"route":"/targets/ccr6/","neighbours":{"target":[{"id":"ccr4","kind":"target","name":"CCR4","route":"/targets/ccr4/"},{"id":"cxcr5","kind":"target","name":"CXCR5","route":"/targets/cxcr5/"}],"term":[{"id":"t-cell","kind":"term","name":"T cell","route":"/terms/t-cell/"}]}}