{"entity":{"id":"ccr7","kind":"target","name":"CCR7","aka":["C-C motif chemokine receptor 7","C-C chemokine receptor type 7","BLR2","CDw197","CD197","CMKBR7","EBI1"],"tldr":"CCR7 (C-C chemokine receptor type 7) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Diffuse large B-cell lymphoma.","summary":"Receptor for the MIP-3-beta chemokine. Probable mediator of EBV effects on B-lymphocytes or of normal lymphocyte functions.\n\nIntOGen calls it a driver in 1 cohort (0 activating, 1 loss-of-function), covering Diffuse Large B-Cell Lymphoma, NOS.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:1608","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:1608"},{"label":"UniProt P32248","url":"https://www.uniprot.org/uniprotkb/P32248/entry"},{"label":"NCBI Gene 1236","url":"https://www.ncbi.nlm.nih.gov/gene/1236"},{"label":"Ensembl ENSG00000126353","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000126353"}],"tags":["cancer-genes-wave"],"related":["intogen"],"cancers":["dlbcl"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it a loss-of-function (LoF) driver in 1 cohort. Evidence tier \"cohort-driver\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"CCR7","role":["tumour-suppressor"],"evidenceTier":"cohort-driver","sources":[{"label":"HGNC HGNC:1608","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:1608","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt P32248","url":"https://www.uniprot.org/uniprotkb/P32248/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"IntOGen CCR7","url":"https://www.intogen.org/search?gene=CCR7","note":"driver in 1 cohort (Act 0, LoF 1); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0"}],"hgnc":"HGNC:1608","ensembl":"ENSG00000126353","uniprot":"P32248","entrez":"1236","biology":"Receptor for the MIP-3-beta chemokine. Probable mediator of EBV effects on B-lymphocytes or of normal lymphocyte functions. Location: Cell membrane (UniProt). Locus 17q21.2 (HGNC).","whereFound":["Diffuse large B-cell lymphoma: IntOGen driver in 1 cohort (DLBCLNOS)"],"targetClass":"tumor-suppressor","prevalence":[]},"route":"/targets/ccr7/","neighbours":{"collection":[{"id":"intogen","kind":"collection","name":"IntOGen","route":"/collections/intogen/"}],"cancer":[{"id":"dlbcl","kind":"cancer","name":"Diffuse large B-cell lymphoma","route":"/cancers/dlbcl/"}]}}