{"entity":{"id":"cd11b","kind":"target","name":"CD11b","aka":["ITGAM","integrin alpha M","Mac-1"],"tldr":"CD11b is carried by most of the myeloid immune cells, and together with CD33 it is part of how myeloid-derived suppressor cells are defined: the cells that hold back a response against a tumour.","summary":"CD11b is integrin alpha M, which pairs with CD18 to form complement receptor 3 and is expressed across neutrophils, monocytes, macrophages and natural killer cells. In oncology its importance is definitional: myeloid-derived suppressor cells have no single marker of their own and are identified by a combination that includes CD11b and CD33, which is why a page on those cells needs this one.","asOf":"2026-10-16","wikipedia":"https://en.wikipedia.org/wiki/Integrin_alpha_M","links":[{"label":"HGNC:6149","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:6149"}],"tags":["immune-marker"],"related":["cd33","cd66b"],"cancers":[],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":["myeloid-derived-suppressor-cells","tumor-microenvironment"],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"symbol":"ITGAM","role":[],"sources":[],"specificitySources":[],"biology":"Integrin alpha M, partner of CD18 in complement receptor 3; broadly expressed across the myeloid line.","whereFound":["Neutrophils","Monocytes and macrophages","Natural killer cells","Myeloid-derived suppressor cells"],"targetClass":"surface-antigen","prevalence":[]},"route":"/targets/cd11b/","neighbours":{"target":[{"id":"cd33","kind":"target","name":"CD33","route":"/targets/cd33/"},{"id":"cd66b","kind":"target","name":"CD66b","route":"/targets/cd66b/"}],"term":[{"id":"myeloid-derived-suppressor-cells","kind":"term","name":"Myeloid-derived suppressor cells (MDSCs)","route":"/terms/myeloid-derived-suppressor-cells/"}],"pathway":[{"id":"tumor-microenvironment","kind":"pathway","name":"Tumour microenvironment (TME)","route":"/pathways/tumor-microenvironment/"}]}}