{"entity":{"id":"cd11c","kind":"target","name":"CD11c","aka":["ITGAX","integrin alpha X"],"tldr":"CD11c identifies dendritic cells, the cells that carry pieces of a tumour to the lymph node and show them to T cells. Without that step, a T cell never learns the cancer is there.","summary":"CD11c is integrin alpha X and the conventional marker of dendritic cells, the professional antigen-presenting cells that take material from a tumour to a draining lymph node and present it to T cells. It is not exclusive to them, appearing on macrophages and some B cells, which is why dendritic subsets are defined by CD11c together with CD1c and CD141. Antigen presentation is the step every immunotherapy depends on, so this is a marker for the beginning of the response rather than its end.","asOf":"2026-10-16","wikipedia":"https://en.wikipedia.org/wiki/Integrin_alpha_X","links":[{"label":"HGNC:6152","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:6152"}],"tags":["immune-marker"],"related":["cd1c","cd141","hla-dr"],"cancers":[],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":["antigen-presentation-immunoediting"],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"symbol":"ITGAX","role":[],"sources":[],"specificitySources":[],"biology":"Integrin alpha X, partner of CD18; the conventional marker of dendritic cells.","whereFound":["Dendritic cells","Monocytes and macrophages","Some B cells"],"targetClass":"surface-antigen","prevalence":[]},"route":"/targets/cd11c/","neighbours":{"target":[{"id":"cd141","kind":"target","name":"CD141","route":"/targets/cd141/"},{"id":"cd1c","kind":"target","name":"CD1c","route":"/targets/cd1c/"},{"id":"hla-dr","kind":"target","name":"HLA-DR","route":"/targets/hla-dr/"}],"pathway":[{"id":"antigen-presentation-immunoediting","kind":"pathway","name":"Antigen presentation & immune editing","route":"/pathways/antigen-presentation-immunoediting/"}]}}