{"entity":{"id":"cd14","kind":"target","name":"CD14","aka":[],"tldr":"CD14 is how a monocyte is recognised: the circulating cell that becomes a macrophage once it enters tissue. Splitting monocytes by CD14 and CD16 is the first step in describing the myeloid side of a tumour.","summary":"CD14 is a co-receptor that presents bacterial lipopolysaccharide to TLR4, and it is the surface marker that defines monocytes. Monocytes are split into classical, intermediate and non-classical subsets by CD14 together with CD16, and that split is the starting point for describing the myeloid compartment of blood or a tumour. Monocytes recruited into a tumour become tumour-associated macrophages, so CD14 is the upstream marker for the cells CD163 later identifies.","asOf":"2026-10-16","wikipedia":"https://en.wikipedia.org/wiki/CD14","links":[{"label":"HGNC:1628","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:1628"}],"tags":["immune-marker"],"related":["fcgr3a","cd163"],"cancers":[],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":["tumor-associated-macrophages","myeloid-derived-suppressor-cells"],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"symbol":"CD14","role":[],"sources":[],"specificitySources":[],"biology":"Co-receptor for bacterial lipopolysaccharide with TLR4; the defining surface marker of monocytes.","whereFound":["Monocytes","Macrophages","Neutrophils at low level"],"targetClass":"surface-antigen","prevalence":[]},"route":"/targets/cd14/","neighbours":{"target":[{"id":"cd163","kind":"target","name":"CD163","route":"/targets/cd163/"},{"id":"fcgr3a","kind":"target","name":"FCGR3A","route":"/targets/fcgr3a/"}],"term":[{"id":"myeloid-derived-suppressor-cells","kind":"term","name":"Myeloid-derived suppressor cells (MDSCs)","route":"/terms/myeloid-derived-suppressor-cells/"},{"id":"tumor-associated-macrophages","kind":"term","name":"Tumour-associated macrophages (TAMs)","route":"/terms/tumor-associated-macrophages/"}]}}