{"entity":{"id":"cd141","kind":"target","name":"CD141","aka":["THBD","thrombomodulin","BDCA-3"],"tldr":"CD141 marks the rare dendritic cells that are best at showing tumour material to killer T cells. The same protein, under its other name thrombomodulin, is part of how blood clotting is kept in check.","summary":"CD141 is thrombomodulin, a cofactor that lets thrombin activate protein C and so restrains clotting on the vessel wall. In immunology it is the marker of conventional type 1 dendritic cells, the scarce subset specialised in cross-presentation, which is the route by which material taken from a dying tumour cell is shown to cytotoxic T cells. The dual identity is worth keeping in mind when reading a result: the same antibody stains endothelium.","asOf":"2026-10-16","wikipedia":"https://en.wikipedia.org/wiki/Thrombomodulin","links":[{"label":"HGNC:11784","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:11784"}],"tags":["immune-marker"],"related":["cd11c","cd1c"],"cancers":[],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":["antigen-presentation-immunoediting"],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"symbol":"THBD","role":[],"sources":[],"specificitySources":[],"biology":"Thrombomodulin, an endothelial anticoagulant cofactor, which also marks the cross-presenting cDC1 dendritic subset.","whereFound":["Conventional type 1 dendritic cells","Vascular endothelium","Monocytes at low level"],"targetClass":"surface-antigen","prevalence":[]},"route":"/targets/cd141/","neighbours":{"target":[{"id":"cd11c","kind":"target","name":"CD11c","route":"/targets/cd11c/"},{"id":"cd1c","kind":"target","name":"CD1c","route":"/targets/cd1c/"}],"pathway":[{"id":"antigen-presentation-immunoediting","kind":"pathway","name":"Antigen presentation & immune editing","route":"/pathways/antigen-presentation-immunoediting/"}]}}