{"entity":{"id":"cd24","kind":"target","name":"CD24","aka":["CD24 molecule","signal transducer CD24","CD24A"],"tldr":"CD24 is a second 'don't eat me' badge after CD47: tumours show it to Siglec-10 on macrophages, which then leave them alone. Blocking antibodies are in first-in-human trials.","summary":"CD24 (chromosome 6q21) is a small GPI-anchored glycoprotein expressed on B cells and the T-cell surface and in erythroleukaemia and small-cell lung carcinoma cell lines; it modulates B-cell activation (UniProt P25063). Normally expressed by immune, epithelial, neural and muscle cells, its interaction with Siglec-10 has been implicated in tumour immune evasion, inhibiting macrophage-mediated phagocytosis as well as NK-cell cytotoxicity; monoclonal antibodies against CD24 have shown clinical safety in two trials, with limited efficacy data (Panagiotou et al. 2022). IMM47, an anti-CD24 antibody, entered a phase 1 study in advanced solid tumours (NCT05985083, status unknown).","asOf":"2026-09-24","links":[{"label":"HGNC HGNC:1645","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:1645"},{"label":"UniProt P25063","url":"https://www.uniprot.org/uniprotkb/P25063/entry"},{"label":"NCBI Gene 100133941","url":"https://www.ncbi.nlm.nih.gov/gene/100133941"},{"label":"Panagiotou et al. 2022, Cancers (Europe PMC)","url":"https://europepmc.org/article/MED/36013184"}],"tags":["checkpoint-map"],"related":["siglec10","cd47","macrophage"],"cancers":[],"sections":[],"technologies":["cd47-blockade"],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":["cancer-immunity-cycle"],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Prevalence not recorded: HGNC and UniProt carry no positivity rates."],"provenance":{"editedBy":"OnCo checkpoint map (HGNC REST, UniProt REST, ClinicalTrials.gov v2)","editedOn":"2026-09-24"},"symbol":"CD24","role":["immune-checkpoint"],"sources":[{"label":"HGNC HGNC:1645","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:1645","note":"approved symbol, name, aliases and cross-references"},{"label":"UniProt P25063","url":"https://www.uniprot.org/uniprotkb/P25063/entry","note":"protein name, function and tissue specificity"}],"specificitySources":[],"hgnc":"HGNC:1645","ensembl":"ENSG00000272398","uniprot":"P25063","entrez":"100133941","biology":"A heavily glycosylated GPI-anchored surface protein; the ligand of Siglec-10.","whereFound":["B cells, T-cell surface (UniProt P25063)","Epithelial tumours, per the cited review"],"targetClass":"checkpoint","prevalence":[]},"route":"/targets/cd24/","neighbours":{"target":[{"id":"cd47","kind":"target","name":"CD47","route":"/targets/cd47/"},{"id":"siglec10","kind":"target","name":"Siglec-10","route":"/targets/siglec10/"}],"term":[{"id":"checkpoint","kind":"term","name":"Checkpoint (two meanings)","route":"/terms/checkpoint/"},{"id":"macrophage","kind":"term","name":"Macrophage","route":"/terms/macrophage/"}],"technology":[{"id":"cd47-blockade","kind":"technology","name":"CD47 and SIRP-alpha blockade","route":"/technologies/cd47-blockade/"}],"pathway":[{"id":"cancer-immunity-cycle","kind":"pathway","name":"The cancer-immunity cycle","route":"/pathways/cancer-immunity-cycle/"}]}}