{"entity":{"id":"cd62l","kind":"target","name":"CD62L","aka":["SELL","L-selectin"],"tldr":"CD62L is the ticket a lymphocyte needs to get into a lymph node. Whether a T cell carries it separates the cells held in reserve from the ones already out working in tissue.","summary":"CD62L is L-selectin, the adhesion receptor that lets a lymphocyte roll along and enter the high endothelial venules of a lymph node. Its presence or absence, read with CCR7, is how naive and central memory cells are told apart from effector memory cells that have left the lymph node circuit for tissue. That distinction is central to cell therapy, where the less differentiated, CD62L-carrying populations are the ones that persist and expand after infusion.","asOf":"2026-10-16","wikipedia":"https://en.wikipedia.org/wiki/L-selectin","links":[{"label":"HGNC:10720","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:10720"}],"tags":["immune-marker"],"related":["ccr7","ptprc"],"cancers":[],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":["t-cell"],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"symbol":"SELL","role":[],"sources":[],"specificitySources":[],"biology":"L-selectin, the homing receptor that lets lymphocytes enter a lymph node across its high endothelial venules.","whereFound":["Naive and central memory T cells","B cells","Neutrophils and monocytes"],"targetClass":"surface-antigen","prevalence":[]},"route":"/targets/cd62l/","neighbours":{"target":[{"id":"ccr7","kind":"target","name":"CCR7","route":"/targets/ccr7/"},{"id":"cd69","kind":"target","name":"CD69","route":"/targets/cd69/"},{"id":"ptprc","kind":"target","name":"PTPRC","route":"/targets/ptprc/"}],"term":[{"id":"t-cell","kind":"term","name":"T cell","route":"/terms/t-cell/"}]}}