{"entity":{"id":"cd66b","kind":"target","name":"CD66b","aka":["CEACAM8","CGM6"],"tldr":"CD66b marks neutrophils, and specifically neutrophils that have been activated. It is the marker used to pick out the granulocyte-like suppressor cells that accumulate in people with advanced cancer.","summary":"CD66b is a granulocyte activation antigen of the carcinoembryonic antigen family, held in secondary granules and brought to the cell surface when a neutrophil is activated. In cancer it is the marker used to identify the granulocytic or polymorphonuclear form of myeloid-derived suppressor cells, the population that expands in advanced disease and suppresses T cell responses. It belongs to the same family as CEACAM5, which this site records as a drug target.","asOf":"2026-10-16","wikipedia":"https://en.wikipedia.org/wiki/CEACAM8","links":[{"label":"HGNC:1820","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:1820"}],"tags":["immune-marker"],"related":["cd11b","ceacam5"],"cancers":[],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":["myeloid-derived-suppressor-cells"],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"symbol":"CEACAM8","role":[],"sources":[],"specificitySources":[],"biology":"Granulocyte activation antigen of the CEA family, stored in secondary granules and brought to the surface on activation.","whereFound":["Neutrophils","Granulocytic myeloid-derived suppressor cells"],"targetClass":"surface-antigen","prevalence":[]},"route":"/targets/cd66b/","neighbours":{"target":[{"id":"cd11b","kind":"target","name":"CD11b","route":"/targets/cd11b/"},{"id":"ceacam5","kind":"target","name":"CEACAM5","route":"/targets/ceacam5/"}],"term":[{"id":"myeloid-derived-suppressor-cells","kind":"term","name":"Myeloid-derived suppressor cells (MDSCs)","route":"/terms/myeloid-derived-suppressor-cells/"}]}}