{"entity":{"id":"cd74","kind":"target","name":"CD74","aka":["CD74 molecule","HLA class II histocompatibility antigen gamma chain","DHLAG"],"tldr":"CD74 (HLA class II histocompatibility antigen gamma chain) is a gene. The public catalogues list it as a drug target and a fusion partner, and an approved or late-stage drug is recorded against it. Tied to Lung cancer and Non-small-cell lung cancer.","summary":"Plays a critical role in MHC class II antigen processing by stabilising peptide-free class II alpha/beta heterodimers in a complex soon after their synthesis and directing transport of the complex from the endoplasmic reticulum to the endosomal/lysosomal system where the antigen processing and binding of antigenic peptides to MHC class II takes place. Serves as cell surface receptor for the cytokine MIF. Binds to the peptide-binding site of MHC class II alpha/beta heterodimers forming an alpha-beta-CLIP complex, thereby preventing the loading of antigenic peptides to the MHC class II complex until its release by HLA-DM in the endosome.\n\nOpen Targets scores its association with cancer at 0.73 (direct and indirect evidence; datatypes literature 0.98, genetic association 0.00, somatic mutation 0.96, clinical 0.89).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:1697","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:1697"},{"label":"UniProt P04233","url":"https://www.uniprot.org/uniprotkb/P04233/entry"},{"label":"NCBI Gene 972","url":"https://www.ncbi.nlm.nih.gov/gene/972"},{"label":"Ensembl ENSG00000019582","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000019582"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":["lung-cancer","nsclc"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: Open Targets known-drug datatype score 0.89; UniProt disease notes describe a translocation or gene fusion involving the gene. Evidence tier \"approved-drug\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"CD74","role":["drug-target","fusion-partner"],"evidenceTier":"approved-drug","sources":[{"label":"HGNC HGNC:1697","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:1697","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt P04233","url":"https://www.uniprot.org/uniprotkb/P04233/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000019582","url":"https://platform.opentargets.org/target/ENSG00000019582/associations","note":"association with cancer (MONDO_0004992) 0.73; per-cancer scores at or above 0.5: non-small cell lung carcinoma 0.68, lung cancer 0.70 (GraphQL API, CC0)"}],"hgnc":"HGNC:1697","ensembl":"ENSG00000019582","uniprot":"P04233","entrez":"972","biology":"Plays a critical role in MHC class II antigen processing by stabilising peptide-free class II alpha/beta heterodimers in a complex soon after their synthesis and directing transport of the complex from the endoplasmic reticulum to the endosomal/lysosomal system where the antigen processing and binding of antigenic peptides to MHC class II takes place. Serves as cell surface receptor for the cytokine MIF. Binds to the peptide-binding site of MHC class II alpha/beta heterodimers forming an alpha-beta-CLIP complex, thereby preventing the loading of antigenic peptides to the MHC class II complex until its release by HLA-DM in the endosome. Stabilises the conformation of mature CTSL by binding to its active site and serving as a chaperone to help maintain a pool of mature enzyme in endocytic compartments and extracellular space of antigen-presenting cells (APCs). Has antiviral activity by stymieing the endosomal entry of Ebola virus and coronaviruses, including SARS-CoV-2. Disrupts cathepsin-mediated Ebola virus glycoprotein processing, which prevents viral fusion and entry. Location: Cell membrane; Endoplasmic reticulum membrane; Golgi apparatus, trans-Golgi network; Endosome (UniProt). Locus 5q33.1 (HGNC).","whereFound":["Lung cancer: Open Targets association 0.70 with lung cancer (MONDO_0008903)","Non-small-cell lung cancer: Open Targets association 0.68 with non-small cell lung carcinoma (MONDO_0005233)"],"targetClass":"other","prevalence":[]},"route":"/targets/cd74/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"lung-cancer","kind":"cancer","name":"Lung cancer (all types)","route":"/cancers/lung-cancer/"},{"id":"nsclc","kind":"cancer","name":"Non-small-cell lung cancer","route":"/cancers/nsclc/"}]}}