{"entity":{"id":"cd79a","kind":"target","name":"CD79A","aka":["CD79a molecule","B-cell antigen receptor complex-associated protein alpha chain","MB-1","Ig-alpha","MB1","IGAlpha"],"tldr":"CD79A (B-cell antigen receptor complex-associated protein alpha chain) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Colorectal cancer, Non-Hodgkin lymphoma and Skin cancer.","summary":"Required in cooperation with CD79B for initiation of the signal transduction cascade activated by binding of antigen to the B-cell antigen receptor complex (BCR) which leads to internalisation of the complex, trafficking to late endosomes and antigen presentation. Also required for BCR surface expression and for efficient differentiation of pro- and pre-B-cells. Stimulates SYK autophosphorylation and activation.\n\nOpen Targets scores its association with cancer at 0.61 (direct and indirect evidence; datatypes literature 0.99, genetic association 0.00, somatic mutation 0.95).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:1698","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:1698"},{"label":"UniProt P11912","url":"https://www.uniprot.org/uniprotkb/P11912/entry"},{"label":"NCBI Gene 973","url":"https://www.ncbi.nlm.nih.gov/gene/973"},{"label":"Ensembl ENSG00000105369","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000105369"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":["colorectal","non-hodgkin-lymphoma","skin-cancer"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier \"association-only\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"CD79A","role":[],"evidenceTier":"association-only","sources":[{"label":"HGNC HGNC:1698","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:1698","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt P11912","url":"https://www.uniprot.org/uniprotkb/P11912/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000105369","url":"https://platform.opentargets.org/target/ENSG00000105369/associations","note":"association with cancer (MONDO_0004992) 0.61; per-cancer scores at or above 0.5: colorectal cancer 0.53, non-Hodgkin lymphoma 0.51, skin cancer 0.50 (GraphQL API, CC0)"}],"hgnc":"HGNC:1698","ensembl":"ENSG00000105369","uniprot":"P11912","entrez":"973","biology":"Required in cooperation with CD79B for initiation of the signal transduction cascade activated by binding of antigen to the B-cell antigen receptor complex (BCR) which leads to internalisation of the complex, trafficking to late endosomes and antigen presentation. Also required for BCR surface expression and for efficient differentiation of pro- and pre-B-cells. Stimulates SYK autophosphorylation and activation. Binds to BLNK, bringing BLNK into proximity with SYK and allowing SYK to phosphorylate BLNK. Also interacts with and increases activity of some Src-family tyrosine kinases. Represses BCR signalling during development of immature B-cells. Location: Cell membrane (UniProt). Locus 19q13.2 (HGNC).","whereFound":["Colorectal cancer: Open Targets association 0.53 with colorectal cancer (MONDO_0005575)","Non-Hodgkin lymphoma: Open Targets association 0.51 with non-Hodgkin lymphoma (MONDO_0018908)","Skin cancer: Open Targets association 0.50 with skin cancer (MONDO_0002898)"],"targetClass":"other","prevalence":[]},"route":"/targets/cd79a/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"colorectal","kind":"cancer","name":"Colorectal cancer","route":"/cancers/colorectal/"},{"id":"non-hodgkin-lymphoma","kind":"cancer","name":"Non-Hodgkin lymphoma (all types)","route":"/cancers/non-hodgkin-lymphoma/"},{"id":"skin-cancer","kind":"cancer","name":"Skin cancer (all types)","route":"/cancers/skin-cancer/"}]}}