{"entity":{"id":"cdc37","kind":"target","name":"CDC37","aka":["cell division cycle 37, HSP90 cochaperone","Hsp90 co-chaperone Cdc37","P50CDC37"],"tldr":"CDC37 (Hsp90 co-chaperone Cdc37) is a gene. In the public catalogues the evidence so far is association rather than a proven role.","summary":"Co-chaperone that binds to numerous kinases and promotes their interaction with the Hsp90 complex, resulting in stabilisation and promotion of their activity. Inhibits HSP90AA1 ATPase activity.\n\nOpen Targets scores its association with cancer at 0.63 (direct and indirect evidence; datatypes literature 0.95, affected pathway 0.99, genetic association 0.00).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:1735","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:1735"},{"label":"UniProt Q16543","url":"https://www.uniprot.org/uniprotkb/Q16543/entry"},{"label":"NCBI Gene 11140","url":"https://www.ncbi.nlm.nih.gov/gene/11140"},{"label":"Ensembl ENSG00000105401","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000105401"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":[],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier \"association-only\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"CDC37","role":[],"evidenceTier":"association-only","sources":[{"label":"HGNC HGNC:1735","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:1735","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q16543","url":"https://www.uniprot.org/uniprotkb/Q16543/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000105401","url":"https://platform.opentargets.org/target/ENSG00000105401/associations","note":"association with cancer (MONDO_0004992) 0.63;  (GraphQL API, CC0)"}],"hgnc":"HGNC:1735","ensembl":"ENSG00000105401","uniprot":"Q16543","entrez":"11140","biology":"Co-chaperone that binds to numerous kinases and promotes their interaction with the Hsp90 complex, resulting in stabilisation and promotion of their activity. Inhibits HSP90AA1 ATPase activity. Location: Cytoplasm (UniProt). Locus 19p13.2 (HGNC).","whereFound":[],"targetClass":"other","prevalence":[]},"route":"/targets/cdc37/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}]}}