{"entity":{"id":"cdc50a","kind":"target","name":"CDC50A","aka":["cell division cycle 50 P4-ATPase accessory subunit A","Cell cycle control protein 50A","FLJ10856","C6orf67","TMEM30A"],"tldr":"CDC50A (Cell cycle control protein 50A) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Diffuse large B-cell lymphoma.","summary":"Accessory component of a P4-ATPase flippase complex which catalyses the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation also seems to be implicated in vesicle formation and in uptake of lipid signalling molecules. The beta subunit may assist in binding of the phospholipid substrate.\n\nCIViC holds 2 clinical evidence items and 0 assertions across 2 variants, naming R-CHOP Regimen.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:16667","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:16667"},{"label":"UniProt Q9NV96","url":"https://www.uniprot.org/uniprotkb/Q9NV96/entry"},{"label":"NCBI Gene 55754","url":"https://www.ncbi.nlm.nih.gov/gene/55754"},{"label":"Ensembl ENSG00000112697","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000112697"}],"tags":["cancer-genes-wave"],"related":["civic"],"cancers":["dlbcl"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC lists 1 therapies; CIViC holds 2 clinical evidence items on its variants. Evidence tier \"clinical-evidence\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"CDC50A","role":["drug-target","biomarker"],"evidenceTier":"clinical-evidence","sources":[{"label":"HGNC HGNC:16667","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:16667","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q9NV96","url":"https://www.uniprot.org/uniprotkb/Q9NV96/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"CIViC gene CDC50A","url":"https://civicdb.org/features/13180","note":"2 evidence items, 0 assertions, 2 variants; diseases: Diffuse Large B-cell Lymphoma (GraphQL API, CC0)"}],"hgnc":"HGNC:16667","ensembl":"ENSG00000112697","uniprot":"Q9NV96","entrez":"55754","biology":"Accessory component of a P4-ATPase flippase complex which catalyses the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation also seems to be implicated in vesicle formation and in uptake of lipid signalling molecules. The beta subunit may assist in binding of the phospholipid substrate. Required for the proper folding, assembly and ER to Golgi exit of the ATP8A2:CDC50A flippase complex. ATP8A2:CDC50A may be involved in regulation of neurite outgrowth, and, reconstituted to liposomes, predomiminantly transports phosphatidylserine (PS) and to a lesser extent phosphatidylethanolamine (PE). The ATP8A1:CDC50A flippase complex seems to play a role in regulation of cell migration probably involving flippase-mediated translocation of phosphatidylethanolamine (PE) at the plasma membrane. Location: Membrane; Cell membrane; Golgi apparatus; Cytoplasmic vesicle, secretory vesicle membrane (UniProt). Locus 6q14.1 (HGNC).","whereFound":["Diffuse large B-cell lymphoma: CIViC evidence names this disease"],"targetClass":"other","prevalence":[]},"route":"/targets/cdc50a/","neighbours":{"collection":[{"id":"civic","kind":"collection","name":"CIViC","route":"/collections/civic/"}],"cancer":[{"id":"dlbcl","kind":"cancer","name":"Diffuse large B-cell lymphoma","route":"/cancers/dlbcl/"}]}}