{"entity":{"id":"cdh10","kind":"target","name":"CDH10","aka":["cadherin 10","Cadherin-10"],"tldr":"CDH10 (Cadherin-10) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver and a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Pancreatic ductal adenocarcinoma, Endometrial cancer and Non-small-cell lung cancer.","summary":"Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.\n\nIntOGen calls it a driver in 6 cohorts (3 activating, 2 loss-of-function), covering Lung Adenocarcinoma, Lung Squamous Cell Carcinoma, Pancreatic Adenocarcinoma, Endometrial Carcinoma.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:1749","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:1749"},{"label":"UniProt Q9Y6N8","url":"https://www.uniprot.org/uniprotkb/Q9Y6N8/entry"},{"label":"NCBI Gene 1008","url":"https://www.ncbi.nlm.nih.gov/gene/1008"},{"label":"Ensembl ENSG00000040731","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000040731"}],"tags":["cancer-genes-wave"],"related":["intogen"],"cancers":["pancreatic","endometrial","nsclc"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 3 cohorts; IntOGen calls it a loss-of-function (LoF) driver in 2 cohorts. Evidence tier \"cohort-driver\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"CDH10","role":["oncogene-driver","tumour-suppressor"],"evidenceTier":"cohort-driver","sources":[{"label":"HGNC HGNC:1749","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:1749","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q9Y6N8","url":"https://www.uniprot.org/uniprotkb/Q9Y6N8/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"IntOGen CDH10","url":"https://www.intogen.org/search?gene=CDH10","note":"driver in 6 cohorts (Act 3, LoF 2); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0"}],"hgnc":"HGNC:1749","ensembl":"ENSG00000040731","uniprot":"Q9Y6N8","entrez":"1008","biology":"Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. Location: Cell membrane (UniProt). Locus 5p14.2-p14.1 (HGNC).","whereFound":["Pancreatic ductal adenocarcinoma: IntOGen driver in 1 cohort (PAAD)","Endometrial cancer: IntOGen driver in 1 cohort (UCEC)","Non-small-cell lung cancer: IntOGen driver in 4 cohorts (LUAD, LUSC)"],"targetClass":"oncogene","prevalence":[]},"route":"/targets/cdh10/","neighbours":{"collection":[{"id":"intogen","kind":"collection","name":"IntOGen","route":"/collections/intogen/"}],"cancer":[{"id":"endometrial","kind":"cancer","name":"Endometrial cancer","route":"/cancers/endometrial/"},{"id":"nsclc","kind":"cancer","name":"Non-small-cell lung cancer","route":"/cancers/nsclc/"},{"id":"pancreatic","kind":"cancer","name":"Pancreatic ductal adenocarcinoma","route":"/cancers/pancreatic/"}]}}