{"entity":{"id":"cdh11","kind":"target","name":"CDH11","aka":["cadherin 11","Cadherin-11","CAD11"],"tldr":"CDH11 (Cadherin-11) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, a tumour suppressor and a fusion partner, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Oesophageal cancer, Gastric & gastro-oesophageal junction cancer, Colorectal cancer and 5 more.","summary":"Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. Required for proper focal adhesion assembly.\n\nOpen Targets scores its association with cancer at 0.74 (direct and indirect evidence; datatypes literature 0.98, genetic association 0.52, somatic mutation 0.90). IntOGen calls it a driver in 7 cohorts (5 activating, 2 loss-of-function), covering Cholangiocarcinoma, Colon Adenocarcinoma, Oesophageal Adenocarcinoma, Hepatocellular Carcinoma, Lung Squamous Cell Carcinoma, Stomach Adenocarcinoma.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:1750","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:1750"},{"label":"UniProt P55287","url":"https://www.uniprot.org/uniprotkb/P55287/entry"},{"label":"NCBI Gene 1009","url":"https://www.ncbi.nlm.nih.gov/gene/1009"},{"label":"Ensembl ENSG00000140937","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000140937"}],"tags":["cancer-genes-wave"],"related":["open-targets","intogen"],"cancers":["esophageal","gastric","colorectal","hcc","breast-cancer","skin-cancer","biliary-tract-cancer","oesophageal-adenocarcinoma"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 5 cohorts; IntOGen calls it a loss-of-function (LoF) driver in 2 cohorts; UniProt disease notes describe a translocation or gene fusion involving the gene. Evidence tier \"cohort-driver\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"CDH11","role":["oncogene-driver","tumour-suppressor","fusion-partner"],"evidenceTier":"cohort-driver","sources":[{"label":"HGNC HGNC:1750","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:1750","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt P55287","url":"https://www.uniprot.org/uniprotkb/P55287/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000140937","url":"https://platform.opentargets.org/target/ENSG00000140937/associations","note":"association with cancer (MONDO_0004992) 0.74; per-cancer scores at or above 0.5: gastric cancer 0.55, oesophageal cancer 0.54, skin cancer 0.51, breast cancer 0.53, biliary tract cancer 0.51 (GraphQL API, CC0)"},{"label":"IntOGen CDH11","url":"https://www.intogen.org/search?gene=CDH11","note":"driver in 7 cohorts (Act 5, LoF 2); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0"}],"hgnc":"HGNC:1750","ensembl":"ENSG00000140937","uniprot":"P55287","entrez":"1009","biology":"Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. Required for proper focal adhesion assembly. Involved in the regulation of cell migration. Location: Cell membrane (UniProt). Locus 16q21 (HGNC).","whereFound":["Oesophageal cancer: Open Targets association 0.54 with oesophageal cancer (MONDO_0007576); IntOGen driver in 2 cohorts (ESCA)","Gastric & gastro-oesophageal junction cancer: Open Targets association 0.55 with gastric cancer (MONDO_0001056); IntOGen driver in 1 cohort (STAD)","Colorectal cancer: IntOGen driver in 1 cohort (COAD)","Hepatocellular carcinoma: IntOGen driver in 1 cohort (HCC)","Breast cancer: Open Targets association 0.53 with breast cancer (MONDO_0007254)","Skin cancer: Open Targets association 0.51 with skin cancer (MONDO_0002898)"],"targetClass":"oncogene","prevalence":[]},"route":"/targets/cdh11/","neighbours":{"collection":[{"id":"intogen","kind":"collection","name":"IntOGen","route":"/collections/intogen/"},{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"biliary-tract-cancer","kind":"cancer","name":"Biliary tract cancer (all types)","route":"/cancers/biliary-tract-cancer/"},{"id":"breast-cancer","kind":"cancer","name":"Breast cancer (all types)","route":"/cancers/breast-cancer/"},{"id":"colorectal","kind":"cancer","name":"Colorectal cancer","route":"/cancers/colorectal/"},{"id":"gastric","kind":"cancer","name":"Gastric & gastro-oesophageal junction cancer","route":"/cancers/gastric/"},{"id":"hcc","kind":"cancer","name":"Hepatocellular carcinoma","route":"/cancers/hcc/"},{"id":"oesophageal-adenocarcinoma","kind":"cancer","name":"Oesophageal and junctional adenocarcinoma","route":"/cancers/oesophageal-adenocarcinoma/"},{"id":"esophageal","kind":"cancer","name":"Oesophageal cancer","route":"/cancers/esophageal/"},{"id":"skin-cancer","kind":"cancer","name":"Skin cancer (all types)","route":"/cancers/skin-cancer/"}]}}