{"entity":{"id":"cdkal1","kind":"target","name":"CDKAL1","aka":["CDKAL1 threonylcarbamoyladenosine tRNA methylthiotransferase","Threonylcarbamoyladenosine tRNA methylthiotransferase","FLJ20342"],"tldr":"CDKAL1 (Threonylcarbamoyladenosine tRNA methylthiotransferase) is an enzyme. In the public catalogues the evidence so far is association rather than a proven role.","summary":"Catalyses the methylthiolation of N6-threonylcarbamoyladenosine (t(6)A), leading to the formation of 2-methylthio-N6-threonylcarbamoyladenosine (ms(2)t(6)A) at position 37 in tRNAs that read codons beginning with adenine.\n\nOpen Targets scores its association with cancer at 0.51 (direct and indirect evidence; datatypes literature 0.72, animal model 0.46, genetic association 0.63).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:21050","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:21050"},{"label":"UniProt Q5VV42","url":"https://www.uniprot.org/uniprotkb/Q5VV42/entry"},{"label":"NCBI Gene 54901","url":"https://www.ncbi.nlm.nih.gov/gene/54901"},{"label":"Ensembl ENSG00000145996","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000145996"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":[],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier \"association-only\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"CDKAL1","role":[],"evidenceTier":"association-only","sources":[{"label":"HGNC HGNC:21050","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:21050","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q5VV42","url":"https://www.uniprot.org/uniprotkb/Q5VV42/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000145996","url":"https://platform.opentargets.org/target/ENSG00000145996/associations","note":"association with cancer (MONDO_0004992) 0.51;  (GraphQL API, CC0)"}],"hgnc":"HGNC:21050","ensembl":"ENSG00000145996","uniprot":"Q5VV42","entrez":"54901","biology":"Catalyses the methylthiolation of N6-threonylcarbamoyladenosine (t(6)A), leading to the formation of 2-methylthio-N6-threonylcarbamoyladenosine (ms(2)t(6)A) at position 37 in tRNAs that read codons beginning with adenine. Location: Endoplasmic reticulum membrane (UniProt). Locus 6p22.3 (HGNC).","whereFound":[],"targetClass":"enzyme","prevalence":[]},"route":"/targets/cdkal1/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}]}}