{"entity":{"id":"cdkn2c","kind":"target","name":"CDKN2C","aka":["cyclin dependent kinase inhibitor 2C","Cyclin-dependent kinase 4 inhibitor C","INK4C","p18"],"tldr":"CDKN2C (Cyclin-dependent kinase 4 inhibitor C) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver and a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Brain and spinal cord tumours and Burkitt lymphoma.","summary":"Interacts strongly with CDK6, weakly with CDK4. Inhibits cell growth and proliferation with a correlated dependence on endogenous retinoblastoma protein RB.\n\nOpen Targets scores its association with cancer at 0.67 (direct and indirect evidence; datatypes affected pathway 0.76, literature 0.94, genetic association 0.22, somatic mutation 0.80, animal model 0.76). IntOGen calls it a driver in 3 cohorts (2 activating, 1 loss-of-function), covering Burkitt Lymphoma, High-Grade Glioma, NOS, Low-Grade Glioma, NOS.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:1789","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:1789"},{"label":"UniProt P42773","url":"https://www.uniprot.org/uniprotkb/P42773/entry"},{"label":"NCBI Gene 1031","url":"https://www.ncbi.nlm.nih.gov/gene/1031"},{"label":"Ensembl ENSG00000123080","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000123080"}],"tags":["cancer-genes-wave"],"related":["open-targets","intogen"],"cancers":["brain-tumours","burkitt-lymphoma"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 2 cohorts; IntOGen calls it a loss-of-function (LoF) driver in 1 cohort. Evidence tier \"cohort-driver\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate.","Diseases the sources name that have no OnCo cancer page yet, so they are not linked: High-Grade Glioma, NOS; Low-Grade Glioma, NOS."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"CDKN2C","role":["oncogene-driver","tumour-suppressor"],"evidenceTier":"cohort-driver","sources":[{"label":"HGNC HGNC:1789","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:1789","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt P42773","url":"https://www.uniprot.org/uniprotkb/P42773/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000123080","url":"https://platform.opentargets.org/target/ENSG00000123080/associations","note":"association with cancer (MONDO_0004992) 0.67; per-cancer scores at or above 0.5: brain cancer 0.50 (GraphQL API, CC0)"},{"label":"IntOGen CDKN2C","url":"https://www.intogen.org/search?gene=CDKN2C","note":"driver in 3 cohorts (Act 2, LoF 1); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0"}],"hgnc":"HGNC:1789","ensembl":"ENSG00000123080","uniprot":"P42773","entrez":"1031","biology":"Interacts strongly with CDK6, weakly with CDK4. Inhibits cell growth and proliferation with a correlated dependence on endogenous retinoblastoma protein RB. Locus 1p32.3 (HGNC).","whereFound":["Brain and spinal cord tumours: Open Targets association 0.50 with brain cancer (MONDO_0001657)","Burkitt lymphoma: IntOGen driver in 1 cohort (BL)"],"targetClass":"oncogene","prevalence":[]},"route":"/targets/cdkn2c/","neighbours":{"collection":[{"id":"intogen","kind":"collection","name":"IntOGen","route":"/collections/intogen/"},{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"brain-tumours","kind":"cancer","name":"Brain and spinal cord tumours (all types)","route":"/cancers/brain-tumours/"},{"id":"burkitt-lymphoma","kind":"cancer","name":"Burkitt lymphoma","route":"/cancers/burkitt-lymphoma/"}]}}