{"entity":{"id":"ceacam1","kind":"target","name":"CEACAM1","aka":["CEA cell adhesion molecule 1","Cell adhesion molecule CEACAM1","BGP1","CD66a"],"tldr":"CEACAM1 (Cell adhesion molecule CEACAM1) is a gene. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Colorectal cancer and Hepatocellular carcinoma.","summary":"Cell adhesion protein that mediates homophilic cell adhesion in a calcium-independent manner. Plays a role as coinhibitory receptor in immune response, insulin action and also functions as an activator during angiogenesis. Its coinhibitory receptor function is phosphorylation- and PTPN6 -dependent, which in turn, suppress signal transduction of associated receptors by dephosphorylation of their downstream effectors.\n\nCIViC holds 3 clinical evidence items and 0 assertions across 2 variants.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:1814","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:1814"},{"label":"UniProt P13688","url":"https://www.uniprot.org/uniprotkb/P13688/entry"},{"label":"NCBI Gene 634","url":"https://www.ncbi.nlm.nih.gov/gene/634"},{"label":"Ensembl ENSG00000079385","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000079385"}],"tags":["cancer-genes-wave"],"related":["civic"],"cancers":["colorectal","hcc"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC holds 3 clinical evidence items on its variants. Evidence tier \"clinical-evidence\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"CEACAM1","role":["biomarker"],"evidenceTier":"clinical-evidence","sources":[{"label":"HGNC HGNC:1814","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:1814","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt P13688","url":"https://www.uniprot.org/uniprotkb/P13688/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"CIViC gene CEACAM1","url":"https://civicdb.org/features/588","note":"3 evidence items, 0 assertions, 2 variants; diseases: Colorectal Cancer, Hepatocellular Carcinoma (GraphQL API, CC0)"}],"hgnc":"HGNC:1814","ensembl":"ENSG00000079385","uniprot":"P13688","entrez":"634","biology":"Cell adhesion protein that mediates homophilic cell adhesion in a calcium-independent manner. Plays a role as coinhibitory receptor in immune response, insulin action and also functions as an activator during angiogenesis. Its coinhibitory receptor function is phosphorylation- and PTPN6 -dependent, which in turn, suppress signal transduction of associated receptors by dephosphorylation of their downstream effectors. Plays a role in immune response, of T cells, natural killer (NK) and neutrophils. Upon TCR/CD3 complex stimulation, inhibits TCR-mediated cytotoxicity by blocking granule exocytosis by mediating homophilic binding to adjacent cells, allowing interaction with and phosphorylation by LCK and interaction with the TCR/CD3 complex which recruits PTPN6 resulting in dephosphorylation of CD247 and ZAP70. Also inhibits T cell proliferation and cytokine production through inhibition of JNK cascade and plays a crucial role in regulating autoimmunity and anti-tumour immunity by inhibiting T cell through its interaction with HAVCR2. Location: Cell membrane; Lateral cell membrane; Apical cell membrane; Basal cell membrane (UniProt). Locus 19q13.2 (HGNC).","whereFound":["Colorectal cancer: CIViC evidence names this disease","Hepatocellular carcinoma: CIViC evidence names this disease"],"targetClass":"other","prevalence":[]},"route":"/targets/ceacam1/","neighbours":{"collection":[{"id":"civic","kind":"collection","name":"CIViC","route":"/collections/civic/"}],"cancer":[{"id":"colorectal","kind":"cancer","name":"Colorectal cancer","route":"/cancers/colorectal/"},{"id":"hcc","kind":"cancer","name":"Hepatocellular carcinoma","route":"/cancers/hcc/"}]}}