{"entity":{"id":"celf2","kind":"target","name":"CELF2","aka":["CUGBP Elav-like family member 2","Etr-3","NAPOR-2","BRUNOL3","CUGBP2"],"tldr":"CELF2 (CUGBP Elav-like family member 2) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role.","summary":"RNA-binding protein implicated in the regulation of several post-transcriptional events. Involved in pre-mRNA alternative splicing, mRNA translation and stability. Mediates exon inclusion and/or exclusion in pre-mRNA that are subject to tissue-specific and developmentally regulated alternative splicing.\n\nOpen Targets scores its association with cancer at 0.52 (direct and indirect evidence; datatypes literature 0.96, genetic association 0.64).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:2550","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:2550"},{"label":"UniProt O95319","url":"https://www.uniprot.org/uniprotkb/O95319/entry"},{"label":"NCBI Gene 10659","url":"https://www.ncbi.nlm.nih.gov/gene/10659"},{"label":"Ensembl ENSG00000048740","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000048740"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":[],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier \"association-only\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"CELF2","role":[],"evidenceTier":"association-only","sources":[{"label":"HGNC HGNC:2550","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:2550","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt O95319","url":"https://www.uniprot.org/uniprotkb/O95319/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000048740","url":"https://platform.opentargets.org/target/ENSG00000048740/associations","note":"association with cancer (MONDO_0004992) 0.52;  (GraphQL API, CC0)"}],"hgnc":"HGNC:2550","ensembl":"ENSG00000048740","uniprot":"O95319","entrez":"10659","biology":"RNA-binding protein implicated in the regulation of several post-transcriptional events. Involved in pre-mRNA alternative splicing, mRNA translation and stability. Mediates exon inclusion and/or exclusion in pre-mRNA that are subject to tissue-specific and developmentally regulated alternative splicing. Specifically activates exon 5 inclusion of TNNT2 in embryonic, but not adult, skeletal muscle. Activates TNNT2 exon 5 inclusion by antagonising the repressive effect of PTB. Acts both as an activator and as a repressor of a pair of coregulated exons: promotes inclusion of the smooth muscle (SM) exon but exclusion of the non-muscle (NM) exon in actinin pre-mRNAs. Location: Nucleus; Cytoplasm (UniProt). Locus 10p14 (HGNC).","whereFound":[],"targetClass":"transcription","prevalence":[]},"route":"/targets/celf2/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}]}}