{"entity":{"id":"cep43","kind":"target","name":"CEP43","aka":["centrosomal protein 43","Centrosomal protein 43","FGFR1OP"],"tldr":"CEP43 (Centrosomal protein 43) is a gene. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role. Tied to Leukaemia, Non-Hodgkin lymphoma and Acute lymphoblastic leukaemia.","summary":"Required for anchoring microtubules to the centrosomes. Required for ciliation.\n\nOpen Targets scores its association with cancer at 0.71 (direct and indirect evidence; datatypes affected pathway 0.95, literature 0.23, genetic association 0.52, somatic mutation 0.49, animal model 0.40).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:17012","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:17012"},{"label":"UniProt O95684","url":"https://www.uniprot.org/uniprotkb/O95684/entry"},{"label":"NCBI Gene 11116","url":"https://www.ncbi.nlm.nih.gov/gene/11116"},{"label":"Ensembl ENSG00000213066","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000213066"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":["leukaemia","non-hodgkin-lymphoma","all-leukemia"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: UniProt disease notes describe a translocation or gene fusion involving the gene. Evidence tier \"association-only\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"CEP43","role":["fusion-partner"],"evidenceTier":"association-only","sources":[{"label":"HGNC HGNC:17012","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:17012","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt O95684","url":"https://www.uniprot.org/uniprotkb/O95684/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000213066","url":"https://platform.opentargets.org/target/ENSG00000213066/associations","note":"association with cancer (MONDO_0004992) 0.71; per-cancer scores at or above 0.5: acute lymphoblastic leukaemia 0.53, non-Hodgkin lymphoma 0.53, leukaemia 0.62 (GraphQL API, CC0)"}],"hgnc":"HGNC:17012","ensembl":"ENSG00000213066","uniprot":"O95684","entrez":"11116","biology":"Required for anchoring microtubules to the centrosomes. Required for ciliation. Location: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome; Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole; Cytoplasm, cytoskeleton, cilium basal body (UniProt). Locus 6q27 (HGNC).","whereFound":["Leukaemia: Open Targets association 0.62 with leukaemia (MONDO_0005059)","Non-Hodgkin lymphoma: Open Targets association 0.53 with non-Hodgkin lymphoma (MONDO_0018908)","Acute lymphoblastic leukaemia: Open Targets association 0.53 with acute lymphoblastic leukaemia (MONDO_0004967)"],"targetClass":"other","prevalence":[]},"route":"/targets/cep43/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"all-leukemia","kind":"cancer","name":"Acute lymphoblastic leukaemia","route":"/cancers/all-leukemia/"},{"id":"leukaemia","kind":"cancer","name":"Leukaemia (all types)","route":"/cancers/leukaemia/"},{"id":"non-hodgkin-lymphoma","kind":"cancer","name":"Non-Hodgkin lymphoma (all types)","route":"/cancers/non-hodgkin-lymphoma/"}]}}