{"entity":{"id":"cep89","kind":"target","name":"CEP89","aka":["centrosomal protein 89","Centrosomal protein of 89 kDa","FLJ14640","CCDC123"],"tldr":"CEP89 (Centrosomal protein of 89 kDa) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Colorectal cancer.","summary":"Required for ciliogenesis. Also plays a role in mitochondrial metabolism where it may modulate complex IV activity.\n\nIntOGen calls it a driver in 1 cohort (1 activating, 0 loss-of-function), covering Colorectal Adenocarcinoma.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:25907","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:25907"},{"label":"UniProt Q96ST8","url":"https://www.uniprot.org/uniprotkb/Q96ST8/entry"},{"label":"NCBI Gene 84902","url":"https://www.ncbi.nlm.nih.gov/gene/84902"},{"label":"Ensembl ENSG00000121289","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000121289"}],"tags":["cancer-genes-wave"],"related":["intogen"],"cancers":["colorectal"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 1 cohort. Evidence tier \"cohort-driver\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"CEP89","role":["oncogene-driver"],"evidenceTier":"cohort-driver","sources":[{"label":"HGNC HGNC:25907","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:25907","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q96ST8","url":"https://www.uniprot.org/uniprotkb/Q96ST8/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"IntOGen CEP89","url":"https://www.intogen.org/search?gene=CEP89","note":"driver in 1 cohort (Act 1, LoF 0); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0"}],"hgnc":"HGNC:25907","ensembl":"ENSG00000121289","uniprot":"Q96ST8","entrez":"84902","biology":"Required for ciliogenesis. Also plays a role in mitochondrial metabolism where it may modulate complex IV activity. Location: Cytoplasm, cytosol; Cytoplasm, cytoskeleton, microtubule organizing center, centrosome; Cytoplasm, cytoskeleton, spindle pole; Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole (UniProt). Locus 19q13.11 (HGNC).","whereFound":["Colorectal cancer: IntOGen driver in 1 cohort (COADREAD)"],"targetClass":"oncogene","prevalence":[]},"route":"/targets/cep89/","neighbours":{"collection":[{"id":"intogen","kind":"collection","name":"IntOGen","route":"/collections/intogen/"}],"cancer":[{"id":"colorectal","kind":"cancer","name":"Colorectal cancer","route":"/cancers/colorectal/"}]}}