{"entity":{"id":"cfi-402411","kind":"drug","name":"CFI-402411","aka":[],"tldr":"CFI-402411 is an experimental small molecule from Treadwell Therapeutics, in phase 1 trials for advanced solid tumours; its current status is not stated.","summary":"CFI-402411 is a small molecule from Treadwell Therapeutics. An oral small-molecule inhibitor of HPK1, tested alone and with pembrolizumab in advanced solid tumours. Its furthest stage is phase 1, for advanced solid tumours. ClinicalTrials.gov registers it in one study linked below. Company pipeline lists TWT-101 as Phase 1 'Actively recruiting', but the registry record NCT04521413 shows overall status UNKNOWN (registered as phase 1/2); the company pipeline page appears out of date. Whether it works in people has not been established unless a trial below reports it.","status":"phase-1","asOf":"2026-11-03","links":[{"label":"Treadwell Therapeutics: treadwelltx.com","url":"https://treadwelltx.com/pipeline/"},{"label":"Treadwell Therapeutics: clinicaltrials.gov","url":"https://clinicaltrials.gov/api/v2/studies/NCT04521413"},{"label":"ClinicalTrials.gov: trials of CFI-402411","url":"https://clinicaltrials.gov/search?intr=CFI-402411"}],"tags":["pipeline","ctgov-ingest"],"related":[],"cancers":["metastatic-cancer"],"sections":[],"technologies":[],"targets":["hpk1"],"drugs":[],"companies":["treadwell-therapeutics"],"institutions":[],"pathways":[],"terms":[],"trials":["nct04521413"],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"provenance":{"editedBy":"OnCo gap audit, class 5 (company pipeline pages and ClinicalTrials.gov v2)","editedOn":"2026-11-03"},"code":"CFI-402411","modality":"Small molecule","mechanism":"An oral small-molecule inhibitor of HPK1, tested alone and with pembrolizumab in advanced solid tumours.","approvals":[],"mechanismSteps":[],"toxicity":[],"access":[],"regulatoryEvents":[]},"route":"/drugs/cfi-402411/","neighbours":{"cancer":[{"id":"metastatic-cancer","kind":"cancer","name":"Metastatic cancer (cancer that has spread)","route":"/cancers/metastatic-cancer/"}],"target":[{"id":"hpk1","kind":"target","name":"HPK1 (MAP4K1)","route":"/targets/hpk1/"}],"company":[{"id":"treadwell-therapeutics","kind":"company","name":"Treadwell Therapeutics","route":"/companies/treadwell-therapeutics/"}],"trial":[{"id":"nct04521413","kind":"trial","name":"Safety and Efficacy Study of CFI-402411 in Subjects With Advanced Solid Malignancies","route":"/trials/nct04521413/"}]}}