{"entity":{"id":"cflar","kind":"target","name":"CFLAR","aka":["CASP8 and FADD like apoptosis regulator","CASP8 and FADD-like apoptosis regulator","Casper","CLARP","FLAME","I-FLICE","c-FLIP","cFLIP","CASP8AP1"],"tldr":"CFLAR (CASP8 and FADD-like apoptosis regulator) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Prostate cancer.","summary":"Apoptosis regulator protein which may function as a crucial link between cell survival and cell death pathways in mammalian cells. Acts as an inhibitor of TNFRSF6 mediated apoptosis. A proteolytic fragment (p43) is likely retained in the death-inducing signalling complex (DISC) thereby blocking further recruitment and processing of caspase-8 at the complex.\n\nCIViC holds 1 clinical evidence item and 0 assertions across 2 variants, naming Bicalutamide.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:1876","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:1876"},{"label":"UniProt O15519","url":"https://www.uniprot.org/uniprotkb/O15519/entry"},{"label":"NCBI Gene 8837","url":"https://www.ncbi.nlm.nih.gov/gene/8837"},{"label":"Ensembl ENSG00000003402","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000003402"}],"tags":["cancer-genes-wave"],"related":["civic"],"cancers":["prostate"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC lists 1 therapies; CIViC holds 1 clinical evidence items on its variants. Evidence tier \"clinical-evidence\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"CFLAR","role":["drug-target","biomarker"],"evidenceTier":"clinical-evidence","sources":[{"label":"HGNC HGNC:1876","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:1876","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt O15519","url":"https://www.uniprot.org/uniprotkb/O15519/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"CIViC gene CFLAR","url":"https://civicdb.org/features/7009","note":"1 evidence items, 0 assertions, 2 variants; diseases: Prostate Cancer (GraphQL API, CC0)"}],"hgnc":"HGNC:1876","ensembl":"ENSG00000003402","uniprot":"O15519","entrez":"8837","biology":"Apoptosis regulator protein which may function as a crucial link between cell survival and cell death pathways in mammalian cells. Acts as an inhibitor of TNFRSF6 mediated apoptosis. A proteolytic fragment (p43) is likely retained in the death-inducing signalling complex (DISC) thereby blocking further recruitment and processing of caspase-8 at the complex. Full length and shorter isoforms have been shown either to induce apoptosis or to reduce TNFRSF-triggered apoptosis. Lacks enzymatic (caspase) activity. Locus 2q33.1 (HGNC).","whereFound":["Prostate cancer: CIViC evidence names this disease"],"targetClass":"other","prevalence":[]},"route":"/targets/cflar/","neighbours":{"collection":[{"id":"civic","kind":"collection","name":"CIViC","route":"/collections/civic/"}],"cancer":[{"id":"prostate","kind":"cancer","name":"Prostate cancer","route":"/cancers/prostate/"}]}}