{"entity":{"id":"chchd7","kind":"target","name":"CHCHD7","aka":["coiled-coil-helix-coiled-coil-helix domain containing 7","Coiled-coil-helix-coiled-coil-helix domain-containing protein 7","MGC2217","COX23"],"tldr":"CHCHD7 (Coiled-coil-helix-coiled-coil-helix domain-containing protein 7) is a gene. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role. Tied to Oral cavity cancer.","summary":"UniProt has no function text for Q9BUK0; HGNC names it \"coiled-coil-helix-coiled-coil-helix domain containing 7\".\n\nOpen Targets scores its association with cancer at 0.56 (direct and indirect evidence; datatypes literature 0.10, genetic association 0.09, somatic mutation 0.89).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:28314","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:28314"},{"label":"UniProt Q9BUK0","url":"https://www.uniprot.org/uniprotkb/Q9BUK0/entry"},{"label":"NCBI Gene 79145","url":"https://www.ncbi.nlm.nih.gov/gene/79145"},{"label":"Ensembl ENSG00000170791","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000170791"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":["oral-cavity-cancer"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: UniProt disease notes describe a translocation or gene fusion involving the gene. Evidence tier \"association-only\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"CHCHD7","role":["fusion-partner"],"evidenceTier":"association-only","sources":[{"label":"HGNC HGNC:28314","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:28314","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q9BUK0","url":"https://www.uniprot.org/uniprotkb/Q9BUK0/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000170791","url":"https://platform.opentargets.org/target/ENSG00000170791/associations","note":"association with cancer (MONDO_0004992) 0.56; per-cancer scores at or above 0.5: oral cavity cancer 0.51 (GraphQL API, CC0)"}],"hgnc":"HGNC:28314","ensembl":"ENSG00000170791","uniprot":"Q9BUK0","entrez":"79145","biology":"UniProt has no function text for Q9BUK0; HGNC names it \"coiled-coil-helix-coiled-coil-helix domain containing 7\". Location: Mitochondrion intermembrane space (UniProt). Locus 8q12.1 (HGNC).","whereFound":["Oral cavity cancer: Open Targets association 0.51 with oral cavity cancer (MONDO_0005515)"],"targetClass":"other","prevalence":[]},"route":"/targets/chchd7/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"oral-cavity-cancer","kind":"cancer","name":"Oral cavity cancer (mouth and tongue)","route":"/cancers/oral-cavity-cancer/"}]}}