{"entity":{"id":"chd4","kind":"target","name":"CHD4","aka":["chromodomain helicase DNA binding protein 4","ATP-dependent chromatin remodeler CHD4","Mi-2b","Mi2-BETA"],"tldr":"CHD4 (ATP-dependent chromatin remodeler CHD4) is a protein that switches other genes on and off. The public catalogues list it as an oncogene driver and a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Endometrial cancer, Colorectal cancer, Renal cell carcinoma and 5 more.","summary":"ATP-dependent chromatin-remodeling factor that binds and distorts nucleosomal DNA. Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin. Localises to acetylated damaged chromatin in a ZMYND8-dependent manner, to promote transcriptional repression and double-strand break repair by homologous recombination.\n\nOpen Targets scores its association with cancer at 0.75 (direct and indirect evidence; datatypes literature 0.98, affected pathway 0.28, genetic association 0.00, somatic mutation 0.95). IntOGen calls it a driver in 9 cohorts (6 activating, 3 loss-of-function), covering Acute Lymphoblastic Leukaemia, Renal Clear Cell Carcinoma, Colon Adenocarcinoma, Head and Neck Squamous Cell Carcinoma, Neuroblastoma, Endometrial Carcinoma and others.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:1919","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:1919"},{"label":"UniProt Q14839","url":"https://www.uniprot.org/uniprotkb/Q14839/entry"},{"label":"NCBI Gene 1108","url":"https://www.ncbi.nlm.nih.gov/gene/1108"},{"label":"Ensembl ENSG00000111642","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000111642"}],"tags":["cancer-genes-wave"],"related":["open-targets","intogen"],"cancers":["endometrial","colorectal","rcc","head-and-neck","skin-cancer","gastric","all-leukemia","clear-cell-rcc"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 6 cohorts; IntOGen calls it a loss-of-function (LoF) driver in 3 cohorts. Evidence tier \"cohort-driver\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"CHD4","role":["oncogene-driver","tumour-suppressor"],"evidenceTier":"cohort-driver","sources":[{"label":"HGNC HGNC:1919","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:1919","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q14839","url":"https://www.uniprot.org/uniprotkb/Q14839/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000111642","url":"https://platform.opentargets.org/target/ENSG00000111642/associations","note":"association with cancer (MONDO_0004992) 0.75; per-cancer scores at or above 0.5: colorectal cancer 0.57, gastric cancer 0.52, endometrial cancer 0.55, melanoma 0.52, skin cancer 0.53 (GraphQL API, CC0)"},{"label":"IntOGen CHD4","url":"https://www.intogen.org/search?gene=CHD4","note":"driver in 9 cohorts (Act 6, LoF 3); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0"}],"hgnc":"HGNC:1919","ensembl":"ENSG00000111642","uniprot":"Q14839","entrez":"1108","biology":"ATP-dependent chromatin-remodeling factor that binds and distorts nucleosomal DNA. Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin. Localises to acetylated damaged chromatin in a ZMYND8-dependent manner, to promote transcriptional repression and double-strand break repair by homologous recombination. Involved in neurogenesis. Location: Nucleus; Cytoplasm, cytoskeleton, microtubule organizing center, centrosome (UniProt). Locus 12p13.31 (HGNC).","whereFound":["Endometrial cancer: Open Targets association 0.55 with endometrial cancer (MONDO_0011962); IntOGen driver in 3 cohorts (UCEC)","Colorectal cancer: Open Targets association 0.57 with colorectal cancer (MONDO_0005575); IntOGen driver in 1 cohort (COAD)","Renal cell carcinoma: IntOGen driver in 1 cohort (CCRCC)","Head and neck squamous cell carcinoma: IntOGen driver in 1 cohort (HNSC)","Skin cancer: Open Targets association 0.53 with skin cancer (MONDO_0002898)","Gastric & gastro-oesophageal junction cancer: Open Targets association 0.52 with gastric cancer (MONDO_0001056)"],"targetClass":"transcription","prevalence":[]},"route":"/targets/chd4/","neighbours":{"collection":[{"id":"intogen","kind":"collection","name":"IntOGen","route":"/collections/intogen/"},{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"all-leukemia","kind":"cancer","name":"Acute lymphoblastic leukaemia","route":"/cancers/all-leukemia/"},{"id":"clear-cell-rcc","kind":"cancer","name":"Clear cell renal cell carcinoma","route":"/cancers/clear-cell-rcc/"},{"id":"colorectal","kind":"cancer","name":"Colorectal cancer","route":"/cancers/colorectal/"},{"id":"endometrial","kind":"cancer","name":"Endometrial cancer","route":"/cancers/endometrial/"},{"id":"gastric","kind":"cancer","name":"Gastric & gastro-oesophageal junction cancer","route":"/cancers/gastric/"},{"id":"head-and-neck","kind":"cancer","name":"Head and neck squamous cell carcinoma","route":"/cancers/head-and-neck/"},{"id":"rcc","kind":"cancer","name":"Renal cell carcinoma","route":"/cancers/rcc/"},{"id":"skin-cancer","kind":"cancer","name":"Skin cancer (all types)","route":"/cancers/skin-cancer/"}]}}