{"entity":{"id":"chd7","kind":"target","name":"CHD7","aka":["chromodomain helicase DNA binding protein 7","ATP-dependent chromatin remodeler CHD7","KIAA1416","FLJ20357","FLJ20361"],"tldr":"CHD7 (ATP-dependent chromatin remodeler CHD7) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Medulloblastoma.","summary":"ATP-dependent chromatin-remodeling factor, slides nucleosomes along DNA; nucleosome sliding requires ATP. Probable transcription regulator. May be involved in the in 45S precursor rRNA production.\n\nIntOGen calls it a driver in 1 cohort (0 activating, 1 loss-of-function), covering Medulloblastoma.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:20626","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:20626"},{"label":"UniProt Q9P2D1","url":"https://www.uniprot.org/uniprotkb/Q9P2D1/entry"},{"label":"NCBI Gene 55636","url":"https://www.ncbi.nlm.nih.gov/gene/55636"},{"label":"Ensembl ENSG00000171316","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000171316"}],"tags":["cancer-genes-wave"],"related":["intogen"],"cancers":["medulloblastoma"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it a loss-of-function (LoF) driver in 1 cohort. Evidence tier \"cohort-driver\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"CHD7","role":["tumour-suppressor"],"evidenceTier":"cohort-driver","sources":[{"label":"HGNC HGNC:20626","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:20626","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q9P2D1","url":"https://www.uniprot.org/uniprotkb/Q9P2D1/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"IntOGen CHD7","url":"https://www.intogen.org/search?gene=CHD7","note":"driver in 1 cohort (Act 0, LoF 1); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0"}],"hgnc":"HGNC:20626","ensembl":"ENSG00000171316","uniprot":"Q9P2D1","entrez":"55636","biology":"ATP-dependent chromatin-remodeling factor, slides nucleosomes along DNA; nucleosome sliding requires ATP. Probable transcription regulator. May be involved in the in 45S precursor rRNA production. Location: Nucleus; Nucleus, nucleolus (UniProt). Locus 8q12.2 (HGNC).","whereFound":["Medulloblastoma: IntOGen driver in 1 cohort (MBL)"],"targetClass":"tumor-suppressor","prevalence":[]},"route":"/targets/chd7/","neighbours":{"collection":[{"id":"intogen","kind":"collection","name":"IntOGen","route":"/collections/intogen/"}],"cancer":[{"id":"medulloblastoma","kind":"cancer","name":"Medulloblastoma","route":"/cancers/medulloblastoma/"}]}}