{"entity":{"id":"chd8","kind":"target","name":"CHD8","aka":["chromodomain helicase DNA binding protein 8","ATP-dependent chromatin remodeler CHD8","KIAA1564","DUPLIN","HELSNF1"],"tldr":"CHD8 (ATP-dependent chromatin remodeler CHD8) is a protein that switches other genes on and off. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Burkitt lymphoma.","summary":"ATP-dependent chromatin-remodeling factor, it slides nucleosomes along DNA; nucleosome sliding requires ATP. Acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. Suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity.\n\nCIViC holds 1 clinical evidence item and 0 assertions across 1 variant.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:20153","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:20153"},{"label":"UniProt Q9HCK8","url":"https://www.uniprot.org/uniprotkb/Q9HCK8/entry"},{"label":"NCBI Gene 57680","url":"https://www.ncbi.nlm.nih.gov/gene/57680"},{"label":"Ensembl ENSG00000100888","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000100888"}],"tags":["cancer-genes-wave"],"related":["civic"],"cancers":["burkitt-lymphoma"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC holds 1 clinical evidence items on its variants. Evidence tier \"clinical-evidence\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"CHD8","role":["biomarker"],"evidenceTier":"clinical-evidence","sources":[{"label":"HGNC HGNC:20153","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:20153","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q9HCK8","url":"https://www.uniprot.org/uniprotkb/Q9HCK8/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"CIViC gene CHD8","url":"https://civicdb.org/features/13968","note":"1 evidence items, 0 assertions, 1 variants; diseases: Burkitt Lymphoma (GraphQL API, CC0)"}],"hgnc":"HGNC:20153","ensembl":"ENSG00000100888","uniprot":"Q9HCK8","entrez":"57680","biology":"ATP-dependent chromatin-remodeling factor, it slides nucleosomes along DNA; nucleosome sliding requires ATP. Acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. Suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity. Acts as a negative regulator of Wnt signalling pathway by regulating beta-catenin (CTNNB1) activity. Negatively regulates CTNNB1-targeted gene expression by being recruited specifically to the promoter regions of several CTNNB1 responsive genes. Involved in both enhancer blocking and epigenetic remodeling at chromatin boundary via its interaction with CTCF. Location: Nucleus (UniProt). Locus 14q11.2 (HGNC).","whereFound":["Burkitt lymphoma: CIViC evidence names this disease"],"targetClass":"transcription","prevalence":[]},"route":"/targets/chd8/","neighbours":{"collection":[{"id":"civic","kind":"collection","name":"CIViC","route":"/collections/civic/"}],"cancer":[{"id":"burkitt-lymphoma","kind":"cancer","name":"Burkitt lymphoma","route":"/cancers/burkitt-lymphoma/"}]}}