{"entity":{"id":"chek1","kind":"target","name":"CHEK1","aka":["checkpoint kinase 1","Serine/threonine-protein kinase Chk1","CHK1"],"tldr":"CHEK1 (Serine/threonine-protein kinase Chk1) is a protein kinase, an enzyme that switches other proteins on by adding phosphate groups. The public catalogues list it as a drug target, a biomarker and a DNA repair gene, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Prostate cancer and Small-cell lung cancer.","summary":"Serine/threonine-protein kinase which is required for checkpoint-mediated cell cycle arrest and activation of DNA repair in response to the presence of DNA damage or unreplicated DNA. May also negatively regulate cell cycle progression during unperturbed cell cycles. This regulation is achieved by a number of mechanisms that together help to preserve the integrity of the genome.\n\nCIViC holds 2 clinical evidence items and 0 assertions across 2 variants, naming Olaparib, Cisplatin and Prexasertib.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:1925","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:1925"},{"label":"UniProt O14757","url":"https://www.uniprot.org/uniprotkb/O14757/entry"},{"label":"NCBI Gene 1111","url":"https://www.ncbi.nlm.nih.gov/gene/1111"},{"label":"Ensembl ENSG00000149554","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000149554"}],"tags":["cancer-genes-wave"],"related":["civic"],"cancers":["prostate","sclc"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":["ddr","replication-stress"],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC lists 3 therapies; CIViC holds 2 clinical evidence items on its variants; UniProt keyword \"DNA repair\". Evidence tier \"clinical-evidence\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"CHEK1","role":["drug-target","biomarker","dna-repair"],"evidenceTier":"clinical-evidence","sources":[{"label":"HGNC HGNC:1925","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:1925","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt O14757","url":"https://www.uniprot.org/uniprotkb/O14757/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"CIViC gene CHEK1","url":"https://civicdb.org/features/981","note":"2 evidence items, 0 assertions, 2 variants; diseases: Lung Small Cell Carcinoma, Castration-resistant Prostate Carcinoma (GraphQL API, CC0)"}],"hgnc":"HGNC:1925","ensembl":"ENSG00000149554","uniprot":"O14757","entrez":"1111","biology":"Serine/threonine-protein kinase which is required for checkpoint-mediated cell cycle arrest and activation of DNA repair in response to the presence of DNA damage or unreplicated DNA. May also negatively regulate cell cycle progression during unperturbed cell cycles. This regulation is achieved by a number of mechanisms that together help to preserve the integrity of the genome. Recognises the substrate consensus sequence [R-X-X-S/T]. Binds to and phosphorylates CDC25A, CDC25B and CDC25C. Phosphorylation of CDC25A at 'Ser-178' and 'Thr-507' and phosphorylation of CDC25C at 'Ser-216' creates binding sites for 14-3-3 proteins which inhibit CDC25A and CDC25C. Location: Nucleus; Chromosome; Cytoplasm; Cytoplasm, cytoskeleton, microtubule organizing center, centrosome (UniProt). Locus 11q24.2 (HGNC).","whereFound":["Prostate cancer: CIViC evidence names this disease","Small-cell lung cancer: CIViC evidence names this disease"],"targetClass":"kinase","prevalence":[]},"route":"/targets/chek1/","neighbours":{"collection":[{"id":"civic","kind":"collection","name":"CIViC","route":"/collections/civic/"}],"cancer":[{"id":"prostate","kind":"cancer","name":"Prostate cancer","route":"/cancers/prostate/"},{"id":"sclc","kind":"cancer","name":"Small-cell lung cancer","route":"/cancers/sclc/"}],"pathway":[{"id":"ddr","kind":"pathway","name":"DNA damage response & homologous recombination","route":"/pathways/ddr/"},{"id":"replication-stress","kind":"pathway","name":"DNA replication stress","route":"/pathways/replication-stress/"}]}}