{"entity":{"id":"chhip","kind":"trial","name":"CHHiP","aka":[],"tldr":"CHHiP showed that four weeks of prostate radiotherapy in 3 Gy fractions is as effective as seven and a half weeks of conventional treatment, and 60 Gy in 20 fractions became the standard of care.","summary":"CHHiP randomised 3,216 men with localised prostate cancer to 74 Gy in 37 fractions, 60 Gy in 20 or 57 Gy in 19, delivered with intensity-modulated radiotherapy and short-course hormone therapy. Five-year biochemical or clinical failure-free survival was 88.3 percent with 74 Gy and 90.6 percent with 60 Gy, proving non-inferiority; 57 Gy did not. Late bowel and bladder effects were similar (Dearnaley and colleagues, Lancet Oncology 2016), and the 60 Gy schedule was adopted internationally.","status":"positive","asOf":"2026-09-16","links":[{"label":"ISRCTN97182923","url":"https://www.isrctn.com/ISRCTN97182923"},{"label":"Lancet Oncology 2016","url":"https://doi.org/10.1016/S1470-2045(16)30102-4"}],"tags":["radiation-wave2"],"related":[],"cancers":["prostate"],"sections":[],"technologies":["hypofractionated-radiotherapy","imrt-igrt"],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":["hypofractionation","alpha-beta-ratio"],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"notes":[],"phase":"3","setting":"Localised prostate cancer: 60 Gy in 20 fractions or 57 Gy in 19 versus 74 Gy in 37 fractions, all with IMRT","sponsor":"Institute of Cancer Research (UK)","result":"5-year biochemical or clinical failure-free survival 90.6% (60 Gy in 20) vs 88.3% (74 Gy in 37), non-inferior.","yearReported":2016,"enrolled":3216,"outcomes":[{"endpoint":"Biochemical or clinical failure-free survival at 5 years","primary":true,"unit":"%","arms":[{"name":"60 Gy in 20 fractions","n":1074,"value":90.6},{"name":"74 Gy in 37 fractions","n":1065,"value":88.3}]}]},"route":"/trials/chhip/","neighbours":{"cancer":[{"id":"prostate","kind":"cancer","name":"Prostate cancer","route":"/cancers/prostate/"}],"technology":[{"id":"hypofractionated-radiotherapy","kind":"technology","name":"Hypofractionated radiotherapy","route":"/technologies/hypofractionated-radiotherapy/"},{"id":"imrt-igrt","kind":"technology","name":"IMRT / IGRT (modern external beam)","route":"/technologies/imrt-igrt/"}],"term":[{"id":"alpha-beta-ratio","kind":"term","name":"Alpha/beta ratio","route":"/terms/alpha-beta-ratio/"},{"id":"hypofractionation","kind":"term","name":"Hypofractionation (fewer, larger radiotherapy doses)","route":"/terms/hypofractionation/"}]}}