{"entity":{"id":"chmp4c","kind":"target","name":"CHMP4C","aka":["charged multivesicular body protein 4C","Charged multivesicular body protein 4c","MGC22825","Shax3","VPS32C"],"tldr":"CHMP4C (Charged multivesicular body protein 4c) is a gene. In the public catalogues the evidence so far is association rather than a proven role.","summary":"Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes.\n\nOpen Targets scores its association with cancer at 0.53 (direct and indirect evidence; datatypes literature 0.91, genetic association 0.66).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:30599","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:30599"},{"label":"UniProt Q96CF2","url":"https://www.uniprot.org/uniprotkb/Q96CF2/entry"},{"label":"NCBI Gene 92421","url":"https://www.ncbi.nlm.nih.gov/gene/92421"},{"label":"Ensembl ENSG00000164695","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000164695"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":[],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier \"association-only\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"CHMP4C","role":[],"evidenceTier":"association-only","sources":[{"label":"HGNC HGNC:30599","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:30599","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q96CF2","url":"https://www.uniprot.org/uniprotkb/Q96CF2/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000164695","url":"https://platform.opentargets.org/target/ENSG00000164695/associations","note":"association with cancer (MONDO_0004992) 0.53;  (GraphQL API, CC0)"}],"hgnc":"HGNC:30599","ensembl":"ENSG00000164695","uniprot":"Q96CF2","entrez":"92421","biology":"Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). Key component of the cytokinesis checkpoint, a process required to delay abscission to prevent both premature resolution of intercellular chromosome bridges and accumulation of DNA damage: upon phosphorylation by AURKB, together with ZFYVE19/ANCHR, retains abscission-competent VPS4 (VPS4A and/or VPS4B) at the midbody ring until abscission checkpoint signalling is terminated at late cytokinesis. Location: Cytoplasm, cytosol; Late endosome membrane; Midbody, Midbody ring (UniProt). Locus 8q21.13 (HGNC).","whereFound":[],"targetClass":"other","prevalence":[]},"route":"/targets/chmp4c/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}]}}