{"entity":{"id":"chrdl1","kind":"target","name":"CHRDL1","aka":["chordin like 1","Chordin-like protein 1","NRLN1","MGC1"],"tldr":"CHRDL1 (Chordin-like protein 1) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts.","summary":"Antagonises the function of BMP4 by binding to it and preventing its interaction with receptors. Alters the fate commitment of neural stem cells from gliogenesis to neurogenesis. Contributes to neuronal differentiation of neural stem cells in the brain by preventing the adoption of a glial fate.\n\nIntOGen calls it a driver in 1 cohort (0 activating, 1 loss-of-function), covering Low-Grade Glioma, NOS.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:29861","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:29861"},{"label":"UniProt Q9BU40","url":"https://www.uniprot.org/uniprotkb/Q9BU40/entry"},{"label":"NCBI Gene 91851","url":"https://www.ncbi.nlm.nih.gov/gene/91851"},{"label":"Ensembl ENSG00000101938","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000101938"}],"tags":["cancer-genes-wave"],"related":["intogen"],"cancers":[],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it a loss-of-function (LoF) driver in 1 cohort. Evidence tier \"cohort-driver\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate.","Diseases the sources name that have no OnCo cancer page yet, so they are not linked: Low-Grade Glioma, NOS."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"CHRDL1","role":["tumour-suppressor"],"evidenceTier":"cohort-driver","sources":[{"label":"HGNC HGNC:29861","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:29861","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q9BU40","url":"https://www.uniprot.org/uniprotkb/Q9BU40/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"IntOGen CHRDL1","url":"https://www.intogen.org/search?gene=CHRDL1","note":"driver in 1 cohort (Act 0, LoF 1); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0"}],"hgnc":"HGNC:29861","ensembl":"ENSG00000101938","uniprot":"Q9BU40","entrez":"91851","biology":"Antagonises the function of BMP4 by binding to it and preventing its interaction with receptors. Alters the fate commitment of neural stem cells from gliogenesis to neurogenesis. Contributes to neuronal differentiation of neural stem cells in the brain by preventing the adoption of a glial fate. May play a crucial role in dorsoventral axis formation. May play a role in embryonic bone formation. May also play an important role in regulating retinal angiogenesis through modulation of BMP4 actions in endothelial cells. Location: Secreted (UniProt). Locus Xq23 (HGNC).","whereFound":[],"targetClass":"tumor-suppressor","prevalence":[]},"route":"/targets/chrdl1/","neighbours":{"collection":[{"id":"intogen","kind":"collection","name":"IntOGen","route":"/collections/intogen/"}]}}