{"entity":{"id":"cic","kind":"target","name":"CIC","aka":["capicua transcriptional repressor","Protein capicua homolog","KIAA0306"],"tldr":"CIC (Protein capicua homolog) is a protein that switches other genes on and off. The public catalogues list it as a drug target, an oncogene driver, a tumour suppressor and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Colorectal cancer, Lung cancer, Pancreatic ductal adenocarcinoma and 4 more.","summary":"Transcriptional repressor which plays a role in development of the central nervous system (CNS). In concert with ATXN1 and ATXN1L, involved in brain development.\n\nCIViC holds 11 clinical evidence items and 0 assertions across 3 variants, naming Trametinib, Vemurafenib and Selumetinib. Open Targets scores its association with cancer at 0.66 (direct and indirect evidence; datatypes literature 0.76, genetic association 0.00, somatic mutation 0.85). IntOGen calls it a driver in 4 cohorts (1 activating, 3 loss-of-function), covering Hepatocellular Carcinoma, Low-Grade Glioma, NOS, Lung Adenocarcinoma.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:14214","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:14214"},{"label":"UniProt Q96RK0","url":"https://www.uniprot.org/uniprotkb/Q96RK0/entry"},{"label":"NCBI Gene 23152","url":"https://www.ncbi.nlm.nih.gov/gene/23152"},{"label":"Ensembl ENSG00000079432","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000079432"}],"tags":["cancer-genes-wave"],"related":["civic","open-targets","intogen"],"cancers":["colorectal","lung-cancer","pancreatic","hcc","skin-cancer","melanoma","nsclc"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":["nct05491525"],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC lists 3 therapies; IntOGen calls it an activating (Act) driver in 1 cohort; IntOGen calls it a loss-of-function (LoF) driver in 3 cohorts; CIViC holds 11 clinical evidence items on its variants. Evidence tier \"clinical-evidence\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate.","Diseases the sources name that have no OnCo cancer page yet, so they are not linked: Low-Grade Glioma, NOS."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"CIC","role":["drug-target","oncogene-driver","tumour-suppressor","biomarker"],"evidenceTier":"clinical-evidence","sources":[{"label":"HGNC HGNC:14214","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:14214","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q96RK0","url":"https://www.uniprot.org/uniprotkb/Q96RK0/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"CIViC gene CIC","url":"https://civicdb.org/features/9326","note":"11 evidence items, 0 assertions, 3 variants; diseases: Lung Cancer, Melanoma, Colon Cancer, Pancreatic Cancer (GraphQL API, CC0)"},{"label":"Open Targets ENSG00000079432","url":"https://platform.opentargets.org/target/ENSG00000079432/associations","note":"association with cancer (MONDO_0004992) 0.66; per-cancer scores at or above 0.5: colorectal cancer 0.54, melanoma 0.55, skin cancer 0.56 (GraphQL API, CC0)"},{"label":"IntOGen CIC","url":"https://www.intogen.org/search?gene=CIC","note":"driver in 4 cohorts (Act 1, LoF 3); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0"}],"hgnc":"HGNC:14214","ensembl":"ENSG00000079432","uniprot":"Q96RK0","entrez":"23152","biology":"Transcriptional repressor which plays a role in development of the central nervous system (CNS). In concert with ATXN1 and ATXN1L, involved in brain development. Location: Nucleus (UniProt). Locus 19q13.2 (HGNC).","whereFound":["Colorectal cancer: Open Targets association 0.54 with colorectal cancer (MONDO_0005575); CIViC evidence names this disease","Lung cancer: CIViC evidence names this disease","Pancreatic ductal adenocarcinoma: CIViC evidence names this disease","Hepatocellular carcinoma: IntOGen driver in 1 cohort (HCC)","Skin cancer: Open Targets association 0.56 with skin cancer (MONDO_0002898)","Melanoma: Open Targets association 0.55 with melanoma (MONDO_0005105); CIViC evidence names this disease"],"targetClass":"transcription","prevalence":[]},"route":"/targets/cic/","neighbours":{"collection":[{"id":"civic","kind":"collection","name":"CIViC","route":"/collections/civic/"},{"id":"intogen","kind":"collection","name":"IntOGen","route":"/collections/intogen/"},{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"colorectal","kind":"cancer","name":"Colorectal cancer","route":"/cancers/colorectal/"},{"id":"hcc","kind":"cancer","name":"Hepatocellular carcinoma","route":"/cancers/hcc/"},{"id":"lung-cancer","kind":"cancer","name":"Lung cancer (all types)","route":"/cancers/lung-cancer/"},{"id":"melanoma","kind":"cancer","name":"Melanoma","route":"/cancers/melanoma/"},{"id":"nsclc","kind":"cancer","name":"Non-small-cell lung cancer","route":"/cancers/nsclc/"},{"id":"pancreatic","kind":"cancer","name":"Pancreatic ductal adenocarcinoma","route":"/cancers/pancreatic/"},{"id":"skin-cancer","kind":"cancer","name":"Skin cancer (all types)","route":"/cancers/skin-cancer/"}],"trial":[{"id":"nct05491525","kind":"trial","name":"Open-label, Long-term Safety, Efficacy, and Pharmacokinetics Study of Vibegron in Pediatric Subjects 2 Years to < 18 Years of Age With NDO and on CIC","route":"/trials/nct05491525/"}]}}