{"entity":{"id":"clip1","kind":"target","name":"CLIP1","aka":["CAP-Gly domain containing linker protein 1","CAP-Gly domain-containing linker protein 1","CYLN1","CLIP170","CLIP-170"],"tldr":"CLIP1 (CAP-Gly domain-containing linker protein 1) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Lung cancer, Cervical cancer, Oesophageal cancer and 2 more.","summary":"Binds to the plus end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes microtubule growth and microtubule bundling. Links cytoplasmic vesicles to microtubules and thereby plays an important role in intracellular vesicle trafficking.\n\nOpen Targets scores its association with cancer at 0.66 (direct and indirect evidence; datatypes literature 0.86, affected pathway 0.93, genetic association 0.00, somatic mutation 0.45). IntOGen calls it a driver in 2 cohorts (0 activating, 2 loss-of-function), covering Cervical Squamous Cell Carcinoma, Oesophageal Squamous Cell Carcinoma.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:10461","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:10461"},{"label":"UniProt P30622","url":"https://www.uniprot.org/uniprotkb/P30622/entry"},{"label":"NCBI Gene 6249","url":"https://www.ncbi.nlm.nih.gov/gene/6249"},{"label":"Ensembl ENSG00000130779","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000130779"}],"tags":["cancer-genes-wave"],"related":["open-targets","intogen"],"cancers":["lung-cancer","cervical","esophageal","nsclc","oesophageal-squamous-cell-carcinoma"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it a loss-of-function (LoF) driver in 2 cohorts. Evidence tier \"cohort-driver\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"CLIP1","role":["tumour-suppressor"],"evidenceTier":"cohort-driver","sources":[{"label":"HGNC HGNC:10461","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:10461","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt P30622","url":"https://www.uniprot.org/uniprotkb/P30622/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000130779","url":"https://platform.opentargets.org/target/ENSG00000130779/associations","note":"association with cancer (MONDO_0004992) 0.66; per-cancer scores at or above 0.5: non-small cell lung carcinoma 0.59, lung cancer 0.60 (GraphQL API, CC0)"},{"label":"IntOGen CLIP1","url":"https://www.intogen.org/search?gene=CLIP1","note":"driver in 2 cohorts (Act 0, LoF 2); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0"}],"hgnc":"HGNC:10461","ensembl":"ENSG00000130779","uniprot":"P30622","entrez":"6249","biology":"Binds to the plus end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes microtubule growth and microtubule bundling. Links cytoplasmic vesicles to microtubules and thereby plays an important role in intracellular vesicle trafficking. Plays a role macropinocytosis and endosome trafficking. Location: Cytoplasm; Cytoplasm, cytoskeleton; Cytoplasmic vesicle membrane; Cell projection, ruffle (UniProt). Locus 12q24.31 (HGNC).","whereFound":["Lung cancer: Open Targets association 0.60 with lung cancer (MONDO_0008903)","Cervical cancer: IntOGen driver in 1 cohort (CESC)","Oesophageal cancer: IntOGen driver in 1 cohort (ESCC)","Non-small-cell lung cancer: Open Targets association 0.59 with non-small cell lung carcinoma (MONDO_0005233)","Oesophageal squamous cell carcinoma: IntOGen driver in 1 cohort (ESCC)"],"targetClass":"tumor-suppressor","prevalence":[]},"route":"/targets/clip1/","neighbours":{"collection":[{"id":"intogen","kind":"collection","name":"IntOGen","route":"/collections/intogen/"},{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"cervical","kind":"cancer","name":"Cervical cancer","route":"/cancers/cervical/"},{"id":"lung-cancer","kind":"cancer","name":"Lung cancer (all types)","route":"/cancers/lung-cancer/"},{"id":"nsclc","kind":"cancer","name":"Non-small-cell lung cancer","route":"/cancers/nsclc/"},{"id":"esophageal","kind":"cancer","name":"Oesophageal cancer","route":"/cancers/esophageal/"},{"id":"oesophageal-squamous-cell-carcinoma","kind":"cancer","name":"Oesophageal squamous cell carcinoma","route":"/cancers/oesophageal-squamous-cell-carcinoma/"}]}}