{"entity":{"id":"clptm1l","kind":"target","name":"CLPTM1L","aka":["CLPTM1 like","Lipid scramblase CLPTM1L","FLJ14400","CRR9"],"tldr":"CLPTM1L (Lipid scramblase CLPTM1L) is a gene. In the public catalogues the evidence so far is association rather than a proven role.","summary":"Scramblase that mediates the translocation of glucosaminylphosphatidylinositol (alpha-D-GlcN-(1-6)-(1,2-diacyl-sn-glycero-3-phospho)-1D-myo-inositol, GlcN-PI) across the endoplasmic reticulum (ER) membrane, from the cytosolic leaflet to the luminal leaflet of the ER membrane, where it participates in the biosynthesis of glycosylphosphatidylinositol (GPI). GPI is a lipid glycoconjugate involved in post-translational modification of proteins. Can also translocate 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) (phosphatidylinositol or PI), as well as several other phospholipids (1,2-diacyl-sn-glycero-3-phosphocholine, 1,2-diacyl-sn-glycero-3-phosphoethanolamine), and N-acetylglucosaminylphosphatidylinositol (GlcNAc-PI) in vitro.\n\nOpen Targets scores its association with cancer at 0.53 (direct and indirect evidence; datatypes literature 0.95, animal model 0.30, genetic association 0.63, somatic mutation 0.23).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:24308","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:24308"},{"label":"UniProt Q96KA5","url":"https://www.uniprot.org/uniprotkb/Q96KA5/entry"},{"label":"NCBI Gene 81037","url":"https://www.ncbi.nlm.nih.gov/gene/81037"},{"label":"Ensembl ENSG00000049656","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000049656"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":[],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier \"association-only\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"CLPTM1L","role":[],"evidenceTier":"association-only","sources":[{"label":"HGNC HGNC:24308","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:24308","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q96KA5","url":"https://www.uniprot.org/uniprotkb/Q96KA5/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000049656","url":"https://platform.opentargets.org/target/ENSG00000049656/associations","note":"association with cancer (MONDO_0004992) 0.53;  (GraphQL API, CC0)"}],"hgnc":"HGNC:24308","ensembl":"ENSG00000049656","uniprot":"Q96KA5","entrez":"81037","biology":"Scramblase that mediates the translocation of glucosaminylphosphatidylinositol (alpha-D-GlcN-(1-6)-(1,2-diacyl-sn-glycero-3-phospho)-1D-myo-inositol, GlcN-PI) across the endoplasmic reticulum (ER) membrane, from the cytosolic leaflet to the luminal leaflet of the ER membrane, where it participates in the biosynthesis of glycosylphosphatidylinositol (GPI). GPI is a lipid glycoconjugate involved in post-translational modification of proteins. Can also translocate 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) (phosphatidylinositol or PI), as well as several other phospholipids (1,2-diacyl-sn-glycero-3-phosphocholine, 1,2-diacyl-sn-glycero-3-phosphoethanolamine), and N-acetylglucosaminylphosphatidylinositol (GlcNAc-PI) in vitro. Location: Endoplasmic reticulum membrane (UniProt). Locus 5p15.33 (HGNC).","whereFound":[],"targetClass":"other","prevalence":[]},"route":"/targets/clptm1l/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}]}}