{"entity":{"id":"cmtr2","kind":"target","name":"CMTR2","aka":["cap methyltransferase 2","Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 2","FLJ11171","MTr2","FTSJD1"],"tldr":"CMTR2 (Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 2) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Non-small-cell lung cancer.","summary":"S-adenosyl-L-methionine-dependent methyltransferase that mediates mRNA cap2 2'-O-ribose methylation to the 5'-cap structure of mRNAs. Methylates the ribose of the second nucleotide of a m(7)GpppG-capped mRNA and small nuclear RNA (snRNA) (cap0) to produce m(7)GpppRmpNm (cap2). Recognises a guanosine cap on RNA independently of its N(7) methylation status.\n\nIntOGen calls it a driver in 1 cohort (0 activating, 1 loss-of-function), covering Lung Adenocarcinoma.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:25635","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:25635"},{"label":"UniProt Q8IYT2","url":"https://www.uniprot.org/uniprotkb/Q8IYT2/entry"},{"label":"NCBI Gene 55783","url":"https://www.ncbi.nlm.nih.gov/gene/55783"},{"label":"Ensembl ENSG00000180917","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000180917"}],"tags":["cancer-genes-wave"],"related":["intogen"],"cancers":["nsclc"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it a loss-of-function (LoF) driver in 1 cohort. Evidence tier \"cohort-driver\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"CMTR2","role":["tumour-suppressor"],"evidenceTier":"cohort-driver","sources":[{"label":"HGNC HGNC:25635","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:25635","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q8IYT2","url":"https://www.uniprot.org/uniprotkb/Q8IYT2/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"IntOGen CMTR2","url":"https://www.intogen.org/search?gene=CMTR2","note":"driver in 1 cohort (Act 0, LoF 1); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0"}],"hgnc":"HGNC:25635","ensembl":"ENSG00000180917","uniprot":"Q8IYT2","entrez":"55783","biology":"S-adenosyl-L-methionine-dependent methyltransferase that mediates mRNA cap2 2'-O-ribose methylation to the 5'-cap structure of mRNAs. Methylates the ribose of the second nucleotide of a m(7)GpppG-capped mRNA and small nuclear RNA (snRNA) (cap0) to produce m(7)GpppRmpNm (cap2). Recognises a guanosine cap on RNA independently of its N(7) methylation status. Display cap2 methylation on both cap0 and cap1. Displays a preference for cap1 RNAs. Location: Nucleus; Cytoplasm (UniProt). Locus 16q22.2 (HGNC).","whereFound":["Non-small-cell lung cancer: IntOGen driver in 1 cohort (LUAD)"],"targetClass":"tumor-suppressor","prevalence":[]},"route":"/targets/cmtr2/","neighbours":{"collection":[{"id":"intogen","kind":"collection","name":"IntOGen","route":"/collections/intogen/"}],"cancer":[{"id":"nsclc","kind":"cancer","name":"Non-small-cell lung cancer","route":"/cancers/nsclc/"}]}}