{"entity":{"id":"cnbp","kind":"target","name":"CNBP","aka":["CCHC-type zinc finger nucleic acid binding protein","RNF163","ZCCHC22","CNBP1","DM2","ZNF9"],"tldr":"CNBP (CCHC-type zinc finger nucleic acid binding protein) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role.","summary":"Single-stranded DNA-binding protein that preferentially binds to the sterol regulatory element (SRE) sequence 5'-GTGCGGTG-3', and thereby mediates transcriptional repression. Has a role as transactivator of the Myc promoter. Binds single-stranded RNA in a sequence-specific manner.\n\nOpen Targets scores its association with cancer at 0.60 (direct and indirect evidence; datatypes literature 0.88, animal model 0.50, genetic association 0.00, somatic mutation 0.93).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:13164","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:13164"},{"label":"UniProt P62633","url":"https://www.uniprot.org/uniprotkb/P62633/entry"},{"label":"NCBI Gene 7555","url":"https://www.ncbi.nlm.nih.gov/gene/7555"},{"label":"Ensembl ENSG00000169714","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000169714"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":[],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier \"association-only\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"CNBP","role":[],"evidenceTier":"association-only","sources":[{"label":"HGNC HGNC:13164","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:13164","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt P62633","url":"https://www.uniprot.org/uniprotkb/P62633/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000169714","url":"https://platform.opentargets.org/target/ENSG00000169714/associations","note":"association with cancer (MONDO_0004992) 0.60;  (GraphQL API, CC0)"}],"hgnc":"HGNC:13164","ensembl":"ENSG00000169714","uniprot":"P62633","entrez":"7555","biology":"Single-stranded DNA-binding protein that preferentially binds to the sterol regulatory element (SRE) sequence 5'-GTGCGGTG-3', and thereby mediates transcriptional repression. Has a role as transactivator of the Myc promoter. Binds single-stranded RNA in a sequence-specific manner. Binds G-rich elements in target mRNA coding sequences. Prevents G-quadruplex structure formation in vitro, suggesting a role in supporting translation by resolving stable structures on mRNAs. Binds to RNA. Location: Nucleus; Cytoplasm; Endoplasmic reticulum (UniProt). Locus 3q21.3 (HGNC).","whereFound":[],"targetClass":"transcription","prevalence":[]},"route":"/targets/cnbp/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}]}}