{"entity":{"id":"cnksr1","kind":"target","name":"CNKSR1","aka":["connector enhancer of kinase suppressor of Ras 1","Connector enhancer of kinase suppressor of ras 1","CNK1"],"tldr":"CNKSR1 (Connector enhancer of kinase suppressor of ras 1) is a gene. In the public catalogues the evidence so far is association rather than a proven role.","summary":"May function as an adapter protein or regulator of Ras signalling pathways.\n\nOpen Targets scores its association with cancer at 0.61 (direct and indirect evidence; datatypes literature 0.65, affected pathway 0.97, genetic association 0.00).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:19700","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:19700"},{"label":"UniProt Q969H4","url":"https://www.uniprot.org/uniprotkb/Q969H4/entry"},{"label":"NCBI Gene 10256","url":"https://www.ncbi.nlm.nih.gov/gene/10256"},{"label":"Ensembl ENSG00000142675","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000142675"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":[],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier \"association-only\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"CNKSR1","role":[],"evidenceTier":"association-only","sources":[{"label":"HGNC HGNC:19700","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:19700","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q969H4","url":"https://www.uniprot.org/uniprotkb/Q969H4/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000142675","url":"https://platform.opentargets.org/target/ENSG00000142675/associations","note":"association with cancer (MONDO_0004992) 0.61;  (GraphQL API, CC0)"}],"hgnc":"HGNC:19700","ensembl":"ENSG00000142675","uniprot":"Q969H4","entrez":"10256","biology":"May function as an adapter protein or regulator of Ras signalling pathways. Location: Cytoplasm; Membrane (UniProt). Locus 1p36.11 (HGNC).","whereFound":[],"targetClass":"other","prevalence":[]},"route":"/targets/cnksr1/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}]}}